5394-63-8

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植物CRISPR/Cas9基因组编辑

锌指核酸酶（ZFN）是由Sigma-Aldrich在不到8年前推出的，但是从那时起靶向基因组编辑技术已迅速发展。最近，CRISPR/Cas9 通路的发现加快了对该领域的兴趣，为研发开辟了新的可能性。

Dopamine, Norepinephrine and Ephinephrine Synthesis

Dopamine-β-hydroxylase is located inside amine storage vesicles of norepinephrine neurons. Dopamine is actively transported from the cytoplasm into the vesicles. As the enzyme is a copper containing protein, its activity can be inhibited by copper chelating agents, such as diethyldithiocarbamate

Determination of 11 Beta Agonist Residues in Pork by LC-MS

Using an Ascentis® Express F5 HPLC column, this study separates 11 β-agonists in pork by LC-MS/MS in under 8 minutes with excellent recovery and precision.

Determination of Eight Aminoglycosides in Pork Meat

LC/LC-MS method identifies 8 aminoglycosides in pork using Discovery® DSC-18 SPE and Ascentis® Express C18 UHPLC, per Chinese standards.

多巴胺、去甲肾上腺素和肾上腺素的合成

多巴胺-β-羟化酶位于去甲肾上腺素神经元的胺存储囊泡内。多巴胺通过主动运输而从细胞质转运到囊泡中。由于该酶是一种含铜的蛋白质，因此其活性会被铜螯合剂，如二乙基二硫代氨基甲酸酯和FLA-63所抑制。对该酶的抑制可有效降低组织去甲肾上腺素的水平。

Detection of Signaling Effector-Complexes Downstream of BMP4 Using In Situ PLA, A Proximity Ligation Assay

BMPs are responsible for a wide range of developmental and biological effects. BMP receptors activate (phosphorylate) the Smad1/5/8 effectors, which then, form a complex with Smad4 and translocate to the nucleus where they function as transcription factors to initiate BMP

Merck gift season, New user’s gift upgrade

默克礼享季新人好礼，焕新升级 2023年6月1日到8月31日，礼享季，新人礼，限时开启。

四唑盐法(MTT)细胞活力和增殖检测方案

检测细胞活力、生长增殖和毒性的四唑盐法(MTT)。四唑盐(MTT)试剂制备说明和应用示例。

一种简单的超滤法蛋白富集

人血浆蛋白质组是生物标志物发现和研究的广阔资源。

组胺合成和代谢

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