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Robert Mynatt et al.
Journal of the Association for Research in Otolaryngology : JARO, 7(2), 182-193 (2006-05-24)
Local applications of drugs to the inner ear are increasingly being used to treat patients' inner ear disorders. Knowledge of the pharmacokinetics of drugs in the inner ear fluids is essential for a scientific basis for such treatments. When auditory
V Novohradský et al.
Dalton transactions (Cambridge, England : 2003), 44(4), 1905-1913 (2014-12-10)
NAMI-A is a ruthenium-based drug endowed with the unique property of selectively targeting solid tumour metastases. Although two clinical studies had already been completed, limited information exists on the behavior of NAMI-A after injection into the bloodstream. PK data in
Alec N Salt
Advances in oto-rhino-laryngology, 59, 140-148 (2002-03-12)
The inner ear fluids are remarkably 'unstirred' so that it cannot be assumed that applied drugs are dispersed throughout the fluid spaces. Calculation of the effective concentrations achieved when drugs are applied directly to the inner ear is made possible
Vincenzo Rispoli et al.
Neuroscience letters, 356(3), 199-202 (2004-03-24)
The effects of two choline pivaloyl esters, [2-(2,2-dimethylpropionyloxy)ethyl]trimethylammonium iodide (1) and [2-(2,2-dimethylpropionyloxy)ethyl]trimethylammonium 2,2-dimethylpropionate (2), on learning and memory impairments induced in rats by scopolamine or lesions of nucleus basalis magnocellularis (NBM) have been evaluated by object recognition and Morris water
Miriam Küpper et al.
Analytical and bioanalytical chemistry, 407(21), 6435-6445 (2015-06-17)
The size, morphology, and chemical composition of particles deposited in the lungs of two nickel refinery workers were studied by scanning and transmission electron microscopy. The particles were extracted from the lung tissue by low-temperature ashing or by dissolution in
Cláudia Margalho et al.
Journal of analytical toxicology, 29(5), 309-313 (2005-08-18)
A simple and rapid method was validated to determine furosemide in whole blood. The experimental work was performed so that all validation parameters are considered simultaneously in a one-day assay protocol. A solid-phase extraction procedure using BondElut-LRC Certify columns was
Anthony A Mikulec et al.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 29(7), 1020-1026 (2008-09-02)
Intratympanic drug delivery has become widely used in the clinic, but little is known regarding how clinically used drug preparations affect round window membrane (RWM) permeability or how much drug is actually delivered to the cochlea. This study evaluated the
Seungjoon Chung et al.
International journal of environmental research and public health, 17(12) (2020-06-25)
This study describes an immobilization method of enriched microorganism, for robustly degrading organic compounds, including tetramethyl ammonium hydroxide (TMAH) in electronics wastewater without an increase of total organic carbon (TOC) in effluent. The enriched TMAH degrading bacteria was entrapped inside
A N Salt et al.
Hearing research, 154(1-2), 88-97 (2001-06-26)
The administration of drugs to the inner ear via the round window membrane is becoming more widely used for both clinical and experimental purposes. The actual drug levels achieved in different regions of the inner ear by this method have
Jian Li et al.
Nanomedicine : nanotechnology, biology, and medicine, 10(7), 1465-1475 (2014-02-04)
Carbon nanotubes (CNTs) are promising drug delivery systems due to their external functionalizable surface and their hollowed cavity that can encapsulate several bioactive molecules. In this study, the chemotherapeutic drug cisplatin or an inert platinum(IV) complex were entrapped inside functionalized-multi-walled-CNTs
Kelly Peeters et al.
Environmental research, 142, 511-521 (2015-08-19)
Biotic and abiotic degradation of toxic organotin compounds (OTCs) in landfill leachates is usually not complete. In this work adsorption and degradation processes of tributyltin (TBT) and trimethyltin (TMeT) in leachate sample treated with different iron nanoparticles (FeNPs): Fe(0) (nZVI)
A Ranz et al.
Journal of biochemical and biophysical methods, 69(1-2), 3-14 (2006-03-28)
In the present study, a derivatization method for the determination of acidic herbicides has been investigated. This procedure involves the methylation with the quaternary ammonium salt trimethylanilinium hydroxide (TMAH) directly in the gas chromatographic auto-sampler vial for analysis by gas
Jeanne Sirovatka Dorweiler et al.
Biochemistry, 42(49), 14653-14662 (2003-12-10)
Cobalamin-dependent methionine synthase (MetH) catalyzes the transfer of methyl groups between methyltetrahydrofolate (CH(3)-H(4)folate) and homocysteine, with the enzyme-bound cobalamin serving as an intermediary in the methyl transfers. An MetH fragment comprising residues 2-649 contains modules that bind and activate CH(3)-H(4)folate
Timothy J Jensen et al.
Journal of photochemistry and photobiology. B, Biology, 100(2), 100-111 (2010-06-19)
Five cationic porphyrins bearing one to four -N(CH(3))(3)(+) groups linked to the p-phenyl positions of 5,10,15,20-tetraphenylporphyrin (TPP) were synthesized in order to study the effect of overall charge and its distribution on the cellular uptake, phototoxicity and intracellular localization using
Marek Majdan et al.
Journal of environmental management, 91(1), 195-205 (2009-09-01)
The comparison of phenol sorption on phenyltrimethylammonium (PTMA)- and benzyltrimethylammonium (BTMA)-bentonite shows a clear difference as far as phenol sorption isotherms are concerned. For PTMA-bentonite the sorption isotherm is of a straight-line character which results from simple partitioning of phenol
Yasser El-Nahhal et al.
Journal of agricultural and food chemistry, 53(5), 1620-1624 (2005-03-03)
This study aimed to evaluate new methodology for designing ecologically acceptable formulations of acetochlor. Modification of montmorillonite with phenyltrimethylammonium chloride (PTMA) or benzyltrimethylammonium chloride (BTMA) and organoclay formulations of acetochlor were prepared in the presence of high concentrations of sodium
Mohammadali Azadfar et al.
International journal of biological macromolecules, 75, 58-66 (2015-01-21)
The structure of lignin obtained from the ozone and soaking aqueous ammonia pretreatment of wheat straw has been characterized utilizing chemical analytical methods in order to reveal its antioxidant characteristics, including attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), pyrolysis-gas chromatography/mass
A N Generalova et al.
Nanoscale, 7(5), 1709-1717 (2014-12-17)
We report a new surface modification approach of upconversion nanoparticles (UCNPs) structured as inorganic hosts NaYF4 codoped with Yb(3+) and Er(3+) based on their encapsulation in a two-stage process of precipitation polymerization of acrolein under alkaline conditions in the presence
Fazel Abdolahpur Monikh et al.
Nature communications, 12(1), 899-899 (2021-02-11)
Analytical limitations considerably hinder our understanding of the impacts of the physicochemical properties of nanomaterials (NMs) on their biological fate in organisms. Here, using a fit-for-purpose analytical workflow, including dosing and emerging analytical techniques, NMs present in organisms are characterized
Estefanía Noriega-Fernández et al.
Foods (Basel, Switzerland), 10(3) (2021-04-04)
The aim of this work was to evaluate the potential of ultrasound (US), alone or in combination with mild heating and/or EDTA towards reduction of As, Cd, I, and Hg content of Laminaria hyperborea. Concentrations of As, Cd, I, and
Joël Teuscher et al.
ChemSusChem, 8(22), 3847-3852 (2015-10-17)
Herein, we present the precise stoichiometric control of methlyammonium lead iodide perovskite thin-films using high vacuum dual-source vapor-phase deposition. We found that UV/Vis absorption and emission spectra were inadequate for assessing precisely the perovskite composition. Alternatively, inductively coupled plasma mass
Alec N Salt et al.
Journal of the Association for Research in Otolaryngology : JARO, 13(6), 771-783 (2012-09-13)
Perilymph pharmacokinetics was investigated by a novel approach, in which solutions containing drug or marker were injected from a pipette sealed into the perilymphatic space of the lateral semi-circular canal (LSCC). The cochlear aqueduct provides the outlet for fluid flow
Simona C Nicoara et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 986-987, 135-142 (2015-03-03)
A proof of principle gas chromatography-mass spectrometry method is presented, in combination with clean up assays, aiming to improve the analysis of methyl mycocerosate tuberculosis biomarkers from sputum. Methyl mycocerosates are generated from the transesterification of phthiocerol dimycocerosates (PDIMs), extracted
Jeffrey T Auletta et al.
Chemico-biological interactions, 187(1-3), 135-141 (2010-05-25)
Acetylcholinesterase (AChE) contains a narrow and deep active site gorge with two sites of ligand binding, an acylation site (or A-site) at the base of the gorge and a peripheral site (or P-site) near the gorge entrance. The P-site contributes
Martina Lorenzetti et al.
Journal of biomaterials applications, 30(1), 71-84 (2015-01-31)
Even though Ti-based implants are the most used materials for hard tissue replacement, they may present lack of osseointegration on the long term, due to their inertness. Hydrothermal treatment (HT) is a useful technique for the synthesis of firmly attached
Kanchanavadee Amphaisri et al.
Journal of chromatography. A, 1218(7), 972-980 (2011-01-11)
On-site verification of the chemical weapon convention (CWC) requires provision for the detection and identification of alkyl phosphonic acids as well as some organic acids that are amenable to GC-MS only after derivatisation. Various derivatisation methods have been used for
Anthony A Mikulec et al.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 30(2), 131-138 (2009-01-31)
Drugs applied to the middle ear enter perilymph through the bony otic capsule. Drugs applied intratympanically in humans are thought to enter the cochlea primarily through the round window membrane (RWM). Local drug treatments of the ear are commonly evaluated
Alec N Salt et al.
Hearing research, 232(1-2), 78-86 (2007-07-31)
Local delivery of drugs to the inner ear is increasingly being used in both clinical and experimental studies. Although direct injection of drugs into perilymph appears to be the most promising way of administering drugs quantitatively, no studies have yet
Alec N Salt et al.
Hearing research, 182(1-2), 24-33 (2003-09-02)
Our understanding of the perilymph kinetics of drugs depends largely on data obtained by the analysis of perilymph samples. Although a number of studies have demonstrated qualitatively that perilymph samples may be contaminated by cerebrospinal fluid (CSF), and some investigations
Irina Shtangeeva et al.
Environmental science and pollution research international, 22(23), 19060-19068 (2015-08-04)
Biogeochemical cycles of bromine (Br) and its quantitative requirements for different plant species are still studied poorly. There is a need to examine Br pathways in plants and evaluate the factors important for Br accumulation in a plant. In the
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