Biologics and Biosimilars Characterization

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facet applications:Biologics and Biosimilars Characterization

facet content type:Technical Article

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Workflow for the Analysis of Polysorbate 80 in Erbitux® Formulation

A complete reversed phase HPLC-ELSD workflow, including sample preparation for the analysis of Polysorbate 80 in a monoclonal antibody formulation.

Enzymes for Antibody Characterization

Antibodies now make up the fastest growing category of therapeutic drugs

Strategies for Deglycosylating N-Linked Glycans

Explore strategies for releasing N-linked glycans with PNGase F, PNGase A & native & sequential deglycosylation with endoglycosidases & exoglycosidases.

O Linked Glycans

O-Linked glycans attachment to peptides involves various residues, particularly GalNAc, known as mucin-type glycans.

Absolute Quantification of Serum Proteome

Protein-AQUA™™ offers robust targeted proteomics for quantitative studies across diverse research areas.

Rapid Glycan Prep & Analysis by LC-MS Workflow

PNGase Fast denaturing buffer and enzyme provide results similar to a conventional 20-hour protocol, reducing workflow time to about 1 hour.

Quantification of Host Cell Proteins

Residual presence of host cell proteins (HCPs) in recombinant therapeutic products has considerable clinical safety risks associated with a potential immunological response in patients.

Simple Digestion Protocol for Proteomics Sample Prep

Rapid trypsin digest kit yields reliable results in less than 2 hours for mass spectrometry analysis.

Rapid Trypsin Digestion of Complex Protein Mixtures for Proteomics Analysis

Reliable and reproducible results in mass spectrometry proteomics analyses are highly dependent on robust sample preparation.

Robust, load independent viral clearance in monoclonal antibody purification with Natrix® Q chromatography membrane

Membrane adsorbers are a cost-effective, robust, single-use solution for monoclonal antibody polishing

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