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Xuan Zhao et al.
Materials science & engineering. C, Materials for biological applications, 55, 201-208 (2015-06-29)
Corneal disease can lead to vision loss. It has become the second greatest cause of blindness in the world, and keratoplasty is considered as an effective treatment method. This paper presents the crosslinked collagen (Col)-citric acid (CA) films developed by
Pallichera Vijayan Shahana et al.
Protein expression and purification, 113, 35-43 (2015-05-12)
Japanese Encephalitis (JE) is a mosquito borne arboviral infection caused by Japanese Encephalitis Virus (JEV). It is a major cause of viral encephalitis in Asian countries including India. In the present study, we have used a Tymovirus [i.e. Physalis Mottle
Francesco De Pascali et al.
Biochemistry, 53(22), 3679-3688 (2014-04-25)
Ischemia-reperfusion injury is accompanied by endothelial hypoxia and reoxygenation that trigger oxidative stress with enhanced superoxide generation and diminished nitric oxide (NO) production leading to endothelial dysfunction. Oxidative depletion of the endothelial NO synthase (eNOS) cofactor tetrahydrobiopterin can trigger eNOS
A Sousa et al.
Journal of chromatography. A, 1355, 125-133 (2014-06-21)
Preparation of high quantities of supercoiled plasmid DNA of pharmaceutical grade purity is a research area where intensive investigation is being performed. From this standpoint, several downstream methods have been proposed, among them the monolithic chromatographic strategies owing to excellent
Giuseppe Fiume et al.
Scientific reports, 5, 13864-13864 (2015-09-08)
Immune activation and chronic inflammation are hallmark features of HIV infection causing T-cell depletion and cellular immune dysfunction in AIDS. Here, we addressed the issue whether HIV-1 Tat could affect T cell development and acute inflammatory response by generating a
Kasper Klein et al.
Journal of microbiological methods, 109, 110-116 (2014-12-30)
Several rod-shaped pathogens including Escherichia coli, Salmonella spp. and Klebsiella pneumonia are capable of adopting highly filamentous cell shapes under certain circumstances. This phenomenon occurs as a result of continued cell elongation during growth without the usual septation into single
Su Bin Wang et al.
Free radical biology & medicine, 83, 41-53 (2015-02-04)
Reactive oxygen species (ROS) generated upon collagen stimulation act as second messengers to propagate various platelet-activating events. Among the ROS-generating enzymes, NADPH oxidase (NOX) plays a prominent role in platelet activation. Thus, NOX has been suggested as a novel target
Miguel Muzzio et al.
Cancer chemotherapy and pharmacology, 75(5), 1015-1023 (2015-03-18)
NSC 743400 is a novel synthetic indenoisoquinoline analog under development as an anticancer agent. It is a potent topoisomerase I inhibitor with potential therapeutic advantages over FDA-approved camptothecin derivatives. In preparation for clinical development of NSC 743400, we determined the
Sana Ehsan et al.
Ecotoxicology and environmental safety, 106, 164-172 (2014-05-21)
Phytoextraction is an eco-friendly and cost-effective technique for removal of toxins, especially heavy metals and metalloids from contaminated soils by the roots of high biomass producing plant species with subsequent transport to aerial parts. Lower metal bioavailability often limits the
Pawel M Bartlewski et al.
Theriogenology, 84(9), 1594-1602 (2015-09-10)
The underlying theme of this study involved the evaluation of the dilatory effects of prostaglandin E2 on the ovine cervix and thus the assessment of its potential applicability to transcervical artificial insemination (TCAI) in ewes. A novel method of prostaglandin
Ines Klingelhöfer et al.
Journal of chromatography. A, 1360, 288-295 (2014-08-26)
The traditional direct bioautography workflow was substantially altered to yield narrow, sharp-bounded effective zones. For the first time, microorganisms quantitatively detected the single effective compounds in complex samples, separated in parallel on a planar chromatogram. This novel effect-directed workflow was
Brad T Casali et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(24), 9173-9181 (2015-06-19)
Alzheimer's disease (AD) is a highly prevalent disorder for which there are no effective therapies. Accumulation of amyloid β (Aβ) peptides in the brain is associated with impaired cognition and memory, pronounced inflammatory dysregulation, and subsequent amyloid plaque deposition. Thus
Takashi Ichinose et al.
Bioscience, biotechnology, and biochemistry, 79(9), 1542-1547 (2015-05-23)
In this study, we examined the effect of orally administrated dipeptides containing Tyr (Y) on the metabolism of catecholamines in mouse brains. We found that among eight synthetic dipeptides whose sequences are present frequently in soy proteins, Ser-Tyr (SY), Ile-Tyr
Francesco Lai et al.
International journal of pharmaceutics, 467(1-2), 27-33 (2014-04-01)
Piroxicam (PRX) is a non-steroidal anti-inflammatory drug characterized by a poor water solubility and consequently by a low oral bioavailability. In this work, different nanocrystal orally disintegrating tablets (ODT) were prepared to enhance piroxicam dissolution rate and saturation solubility. PRX
Dariela Almeda et al.
Biomaterials, 41, 37-44 (2014-12-20)
Liposomes may be engineered to target inflamed endothelium by mimicking ligand-receptor interactions between leukocytes and cytokine-activated endothelial cells (ECs). The upregulation and assembly of vascular cell adhesion molecule-1 (VCAM1) and E-selectin on the cell membrane upon exposure to cytokines have
Richard J Stevenson et al.
Neurocase, 21(1), 33-43 (2013-12-07)
Lesions of the insula can affect olfaction and gustation. Here, we examined the effect of insula lesions on taste and taste-like experiences generated via smelling (i.e., odor-induced tastes) in patients with focal insula lesions and intact olfaction. From a set
Rhabdomyolysis-related renal tubular damage studied by proton nuclear magnetic resonance spectroscopy of urine.
Eleni Bairaktari et al.
Clinical chemistry, 48(7), 1106-1109 (2002-06-29)
Modulation of GABAA receptor signaling increases neurogenesis and suppresses anxiety through NFATc4.
Giorgia Quadrato et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(25), 8630-8645 (2014-06-21)
Correlative evidence suggests that GABAergic signaling plays an important role in the regulation of activity-dependent hippocampal neurogenesis and emotional behavior in adult mice. However, whether these are causally linked at the molecular level remains elusive. Nuclear factor of activated T
Virendra Kumar et al.
Ultrastructural pathology, 39(1), 38-48 (2014-09-06)
The aim of this study was to investigate the morphologic and ultrastructural features of biofilms of slow and fast-growing mycobacteria in different stress conditions, presence and absence of oleic acid albumin dextrose catalase (OADC) enrichment and at different temperatures: 30
Morgan Solliec et al.
Rapid communications in mass spectrometry : RCM, 29(24), 2361-2373 (2015-11-14)
Swine manure can contain a wide range of veterinary antibiotics, which could enter the environment via manure spreading on agricultural fields. A suspect and non-target screening method was applied to swine manure samples to attempt to identify veterinary antibiotics and
Sry D Hujaya et al.
Pharmaceutical research, 32(9), 3066-3086 (2015-04-09)
To investigate the properties of phenylboronic acid-functional poly(amido amine) polymers (BA-PAA) in forming multilayered thin films with poly(vinyl alcohol) (PVA) and chondroitin sulfate (ChS), and to evaluate their compatibility with COS-7 cells. Copolymers of phenylboronic acid-functional poly(amido amine)s, differing in
Agnieszka Korzeniowska-Kowal et al.
PloS one, 10(6), e0129492-e0129492 (2015-06-19)
Lipopolysaccharide (LPS), the major component of the outer membrane of Gram-negative bacteria, contains the O-polysaccharide, which is important to classify bacteria into different O-serological types within species. The O-polysaccharides of serotypes O24 and O56 of E. coli contain sialic acid
Laura M Davison et al.
Arthritis & rheumatology (Hoboken, N.J.), 67(4), 1012-1022 (2014-12-17)
Patients with systemic lupus erythematosus (SLE) often present with elevated levels of interferon-α (IFNα) in serum. Plasmacytoid dendritic cells (pDCs) have been suggested to be the primary source of IFNα in SLE due to their capacity to produce high levels
Xixi Zhou et al.
The Journal of biological chemistry, 290(30), 18361-18369 (2015-06-13)
Cysteine oxidation induced by reactive oxygen species (ROS) on redox-sensitive targets such as zinc finger proteins plays a critical role in redox signaling and subsequent biological outcomes. We found that arsenic exposure led to oxidation of certain zinc finger proteins
Toni Llorente-Mirandes et al.
Food chemistry, 194, 849-856 (2015-10-17)
The present study reports arsenic analysis in Lentinula edodes, Agaricus bisporus and Pleurotus ostreatus before and after being cooked. Furthermore, arsenic in raw and cooked mushroom was determined in the gastric and gastrointestinal bioaccessible fractions obtained after simulating human digestion
David M Foureau et al.
Cancer immunology, immunotherapy : CII, 63(12), 1329-1340 (2014-09-11)
Interleukin-2 (IL-2) therapy leads to clinically relevant responses in 10-16 % of patients with metastatic melanoma (MMEL) or 10-30 % of patients with metastatic renal cell carcinoma (MRCC). To date, no biomarkers have been validated to identify patients who are likely to
Kate L Lowe et al.
Blood, 125(24), 3769-3777 (2015-04-25)
Mice with a constitutive or platelet-specific deletion of the C-type-lectin-like receptor (CLEC-2) exhibit hemorrhaging in the brain at mid-gestation. We sought to investigate the basis of this defect, hypothesizing that it is mediated by the loss of CLEC-2 activation by
Chao Tang et al.
Biochimica et biophysica acta, 1850(7), 1438-1448 (2015-04-19)
Epithelial to mesenchymal transition (EMT) is critical for human placental development, trophoblastic differentiation, and pregnancy-associated diseases. Here, we investigated the effects of hedgehog (HH) signaling on EMT in human trophoblasts, and further explored the underlying mechanism. Human primary cytotrophoblasts and
Alex Russell et al.
Cognitive neuroscience, 6(2-3), 77-88 (2015-04-22)
Odors are often difficult to identify, and can be perceived either via the nose or mouth ("flavor"; not usually perceived as a "smell"). These features provide a unique opportunity to contrast conceptual and perceptual accounts of synesthesia. We presented six
Minghan Xu et al.
Nanoscale, 7(23), 10527-10534 (2015-05-28)
Carbon quantum dots (CQDs) are novel carbon nanomaterials and are attracting increasing interest due to their good characteristics such as hydrophilicity, chemical stability, quantum yield, small particle sizes, and low cytotoxicity. Herein, we used CQDs as stabilizers and exfoliation agents
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