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  • Insula to ventral striatal projections mediate compulsive eating produced by intermittent access to palatable food.

Insula to ventral striatal projections mediate compulsive eating produced by intermittent access to palatable food.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology (2019-10-09)
Samantha Spierling, Giordano de Guglielmo, Dean Kirson, Alison Kreisler, Marisa Roberto, Olivier George, Eric P Zorrilla
摘要

Compulsive eating characterizes many binge-related eating disorders, yet its neurobiological basis is poorly understood. The insular cortex subserves visceral-emotional functions, including taste processing, and is implicated in drug craving and relapse. Here, via optoinhibition, we implicate projections from the anterior insular cortex to the nucleus accumbens as modulating highly compulsive-like food self-administration behaviors that result from intermittent access to a palatable, high-sucrose diet. We identified compulsive-like eating behavior in female rats through progressive ratio schedule self-administration and punishment-resistant responding, food reward tolerance and escalation of intake through 24-h energy intake and fixed-ratio operant self-administration sessions, and withdrawal-like irritability through the bottle brush test. We also identified an endocrine profile of heightened GLP-1 and PP but lower ghrelin that differentiated rats with the most compulsive-like eating behavior. Measures of compulsive eating severity also directly correlated to leptin, body weight and adiposity. Collectively, this novel model of compulsive-like eating symptoms demonstrates adaptations in insula-ventral striatal circuitry and metabolic regulatory hormones that warrant further study.

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Protease Inhibitor Cocktail, for use with mammalian cell and tissue extracts, DMSO solution
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恩波吡维铵 双羟萘酸盐 水合物, ≥98% (HPLC)
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MILLIPLEX® 大鼠代谢激素磁珠面板-代谢多重检测, The analytes available for this multiplex kit are: Amylin (Active), C-Peptide 2, Ghrelin (Active), GIP (Total), GLP-1 (Active), Glucagon, IL-6, Insulin, Leptin, MCP-1, PP, PYY, TNF-α.
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500 mL
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¥659.76
500 mL
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2.5 L
预计发货时间 2025年8月28日
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¥1,551.46