Concise total synthesis of (-)-8-epigrosheimin.

Concise total synthesis of (-)-8-epigrosheimin.

Organic letters (2011-06-17)

Haishen Yang, Yuzhe Gao, Xiaoxiao Qiao, Longguan Xie, Xiaohua Xu

摘要

A highly efficient route was developed to synthesize (-)-8-epigrosheimin in four steps from aldehyde 2 based on a substrate-controlled method. The key steps of the synthesis included (1) a stereo- and regioselective allylation addition, (2) an intramolecular translactonization, and (3) an aldehyde-ene cyclization.

材料

产品编号

品牌

产品描述

124931

Sigma-Aldrich

(R)-(-)-香芹酮, 98%

435759

Sigma-Aldrich

(S)-(+)-香芹酮, 96%

W224928

Sigma-Aldrich