Merck
CN
  • Preparation of biodegradable polylactide microparticles via a biocompatible procedure.

Preparation of biodegradable polylactide microparticles via a biocompatible procedure.

Macromolecular bioscience (2012-03-01)
Riccardo Levato, Miguel A Mateos-Timoneda, Josep A Planell
摘要

PLA MPs are prepared via a novel and toxic-chemical-free fabrication route using ethyl lactate, a green solvent and FDA-approved aroma. MPs are obtained by a solution jet break-up and solvent displacement method. Adjusting flow parameters allows the tuning of MPs size between 60 and 180 µm, with reduced polydispersity. Morphological analysis shows microporous particles with Janus-like surface. A fluorophore is successfully loaded into the MPs during their formation step. This versatile green solvent-based procedure is proven to be suitable for drug encapsulation and delivery applications. The method may be extended to different droplet generation techniques.

材料
货号
品牌
产品描述

Sigma-Aldrich
(-)-L-乳酸乙酯, 98%
Sigma-Aldrich
乳酸乙酯, ≥98%, FCC, FG
Sigma-Aldrich
乳酸乙酯, natural, ≥98%, FCC, FG
Sigma-Aldrich
(-)-L-乳酸乙酯, purum, ≥98.0% (sum of enantiomers, GC)
Sigma-Aldrich
(-)-L-乳酸乙酯, photoresist grade, ≥99.0%