Diastereoselective synthesis of 5-hydroxy-8-methoxy-1-oxaspiro[5,5]undeca-7,10-diene-9-one.

Diastereoselective synthesis of 5-hydroxy-8-methoxy-1-oxaspiro[5,5]undeca-7,10-diene-9-one.

Molecules (Basel, Switzerland) (2013-01-25)

Guy L Plourde, Thomas W Scully

摘要

A short five steps synthesis of the title compound from vanillin is described. The racemic spiroether 7 was obtained in 61% yield and in >99% diastereomeric excess (by 1H-NMR) from the corresponding phenolic derivative 3 by oxidation with lead (IV) acetate.

材料

产品编号

品牌

产品描述

V1104

Sigma-Aldrich

香草醛, ReagentPlus^®, 99%

PHR1091

Supelco

香草醛熔点标准品, Pharmaceutical Secondary Standard; Certified Reference Material

W310727

Sigma-Aldrich