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Surface functionality as a means to impact polymer nanoparticle size and structure.

Surface functionality as a means to impact polymer nanoparticle size and structure.

Langmuir : the ACS journal of surfaces and colloids (2013-02-27)

Julia Schneider, Andrew P Jallouk, Daniela Vasquez, Ralf Thomann, Aurélien Forget, Christopher J Pino, V Prasad Shastri

摘要

When polymeric nanoparticles (NPs) are formed by nanoprecipitation, which is a nucleation-growth process, the control over size requires changing the polymer concentration or solvent composition. Here, we demonstrate that the NP size can be controlled independent of polymer variables by introducing a polyelectrolyte (PE) in the aqueous phase. PEs that exhibit hydrogen bonding (H-bonding) yield a reduction in NP size, whereas PEs that do not possess this characteristic promote the formation of larger NPs. The observed effect can be attributed to the formation of a diffusional barrier around the NP in the form of a dense shell. This principle of controlling NP size is not limited to polymers and can also be employed in the production of lipid NPs.

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聚丙烯酸

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聚(4-苯乙烯磺酸) 溶液, M_w ~75,000, 18 wt. % in H₂O

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聚丙烯酸溶液, average M_w ~250,000, 35 wt. % in H₂O

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聚丙烯酸钠, average M_w ~5,100 by GPC, powder

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聚丙烯酸溶液, average M_w ~100,000, 35 wt. % in H₂O

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聚(4-苯乙烯磺酸钠), average M_w ~1,000,000, powder

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聚(4-苯乙烯磺酸钠) 溶液, average M_w ~200,000, 30 wt. % in H₂O

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聚丙烯酸, average M_v ~1,250,000

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聚丙烯酸钠, average M_w ~2,100

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聚乙烯（丙烯酸，钠盐）溶液, 45 wt. % in H₂O

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聚(4-苯乙烯磺酸钠) 溶液, average M_w ~70,000, 30 wt. % in H₂O

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聚丙烯酸, average M_v ~4,000,000

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聚丙烯酸, average M_v ~3,000,000

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聚丙烯酸, analytical standard, average M_n 130,000 (Typical)

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聚丙烯酸钠, analytical standard, suitable for gel permeation chromatography (GPC), 16,000

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