- [Effect of anticonvulsants on the nitric oxide system].
[Effect of anticonvulsants on the nitric oxide system].
Ukrains'kyi biokhimichnyi zhurnal (1999 ) (2013-03-29)
L A Gromov, I F Belenichev, L G Gonchar-Cherdakli, G A Zhernovaia
PMID23534293
摘要
The effect of phenobarbital, carbamazepine, valproate sodium, depakine, topiramate and lamotrigine on the content of NO and NO-synthase activity in white rat brain tissues has been studied. It was established that the action of carbamazepine, valproate sodium, topiramate and lamotrigine decreases the activity of NO-synthase and the level of NO in the brain tissues. The amount of NO does not change while NO-synthase activity increases with the introduction of phenobarbital. The involvement of nitric oxide in the mechanism of action of the studied anticonvulsant drugs is discussed.
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Supelco
卡马西平标准液 溶液, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
Supelco
丙戊酸标准液 溶液, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®