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Investigating the anti-leishmanial effects of linear peptoids.

Investigating the anti-leishmanial effects of linear peptoids.

ChemMedChem (2014-12-17)

Gabriela A Eggimann, Hannah L Bolt, Paul W Denny, Steven L Cobb

摘要

Peptoids, a class of peptide mimetics, have emerged as promising anti-infective agents against a range of bacterial infections. Herein we present the first study of the antiparasitic and specifically the anti-leishmanial properties of linear peptoids. Peptoids were identified as having promising activity against Leishmania mexicana axenic amastigotes, a causative agent of cutaneous leishmaniasis.

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