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5-Fluorouracil intercalated iron oxide@layered double hydroxide core-shell nano-composites with isotropic and anisotropic architectures for shape-selective drug delivery applications.

5-Fluorouracil intercalated iron oxide@layered double hydroxide core-shell nano-composites with isotropic and anisotropic architectures for shape-selective drug delivery applications.

Materials science & engineering. C, Materials for biological applications (2015-06-29)

Gülsevde Tuncelli, Ahmet Nedim Ay, Birgül Zümreoglu-Karan

摘要

We report the synthesis, characterization and in vitro release behavior of anti-cancer drug carrying iron oxide@layered double hydroxide core-shell nanocomposites with sizes ranging from 40 to 300 nm, good drug loading capacities and soft ferromagnetic properties. HRTEM analyses verified that nearly spherical isotropic carriers were obtained by coating spherical magnetite particles while anisotropic carriers were obtained by coating spindle-shaped hematite particles. They both displayed a fluctuating in vitro release profile with a higher release percentage for the anisotropic carrier.

材料

产品编号

品牌

产品描述

Sigma-Aldrich

5-氟脲嘧啶, ≥99% (HPLC), powder

Sigma-Aldrich

氧化铁(II,III), nanopowder, 50-100 nm particle size (SEM), 97% trace metals basis

Sigma-Aldrich

氧化铁(II,III), powder, <5 μm, 95%

Sigma-Aldrich

氧化铁(II,III), 99.99% trace metals basis

Sigma-Aldrich

氧化铁(II,III)，磁性纳米颗粒溶液, 10 nm avg. part. size, 5 mg/mL in toluene

Sigma-Aldrich

氧化铁(II,III)，磁性纳米颗粒溶液, 30 nm avg. part. size (TEM), PEG functionalized, 1 mg/mL Fe in H₂O, dispersion

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氧化铁(II,III)，磁性纳米颗粒溶液, 10 nm avg. part. size, 5 mg/mL in H₂O

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氧化铁(II,III)，磁性纳米颗粒溶液, 5 nm avg. part. size, 5 mg/mL in H₂O

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氧化铁(II,III)，磁性纳米颗粒溶液, 10 nm avg. part. size (TEM), carboxylic acid functionalized, 5 mg/mL Fe in H₂O, dispersion

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氧化铁(II,III)，磁性纳米颗粒溶液, 20 nm avg. part. size, 5 mg/mL in H₂O

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氧化铁(II,III)，磁性纳米颗粒溶液, 30 nm avg. part. size (TEM), amine functionalized, 1 mg/mL Fe in H₂O, dispersion

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氧化铁(II,III)，磁性纳米颗粒溶液, 5 nm avg. part. size, 5 mg/mL in toluene

Sigma-Aldrich

氧化铁(II,III)，磁性纳米颗粒溶液, 20 nm avg. part. size, 5 mg/mL in toluene

Sigma-Aldrich

氧化铁(II,III)，磁性纳米颗粒溶液, 10 nm avg. part. size (TEM), PEG functionalized, 1 mg/mL Fe in H₂O, dispersion

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氧化铁(II,III)，磁性纳米颗粒溶液, 10 nm avg. part. size (TEM), amine functionalized, 1 mg/mL Fe in H₂O, dispersion

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氟脲嘧啶, meets USP testing specifications

Sigma-Aldrich

氧化铁(II,III)，磁性纳米颗粒溶液, 5 nm avg. part. size (TEM), PEG functionalized, 1 mg/mL Fe in H₂O, dispersion

Sigma-Aldrich

氧化铁(II,III)，磁性纳米颗粒溶液, 5 nm avg. part. size (TEM), amine functionalized, 1 mg/mL Fe in H₂O, dispersion

Sigma-Aldrich

5-氟脲嘧啶, Vetec^™, reagent grade, ≥99%