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  • Concentrating carbohydrates before sleep improves feeding regulation and metabolic and inflammatory parameters in mice.

Concentrating carbohydrates before sleep improves feeding regulation and metabolic and inflammatory parameters in mice.

Molecular and cellular endocrinology (2015-07-25)
Sigal Sofer, Abraham Eliraz, Zecharia Madar, Oren Froy
摘要

New evidance highlights the importance of food timing. Recently, we showed that a low-calorie diet with carbohydrates eaten mostly at dinner changed diurnal hormone secretion and led to greater weight loss and improved metabolic status in obese people. Herein, we set out to test whether concentrated-carbohydrates diet (CCD), in which carbohydrates are fed only before sleep, leads to an improved metabolic status in mouse hypothalamus and peripheral tissues. Diet-induced obese mice were given concentrated or distributed carbohydrate diet for 6 weeks. Obese mice fed CCD ate 8.3% less, were 9.3% leaner and had 39.7% less fat mass. Leptin, ghrelin and adiponectin displayed altered secretion. In addition, these mice exhibited an improved biochemical and inflammatory status. In the hypothalamus, anorexigenic signals were up-regulated and orexigenic signals were down-regulated. In peripheral tissues, CCD promoted adiponectin signaling, repressed gluconeogenesis, enhanced lipid oxidation and lowered inflammation, thus ameliorating the major risk factors of obesity.

材料
Product Number
品牌
产品描述

Sigma-Aldrich
胆固醇, Sigma Grade, ≥99%
Sigma-Aldrich
胆固醇, powder, BioReagent, suitable for cell culture, ≥99%
Sigma-Aldrich
SyntheChol ® NS0 补充, 500 ×, synthetic cholesterol, animal component-free, aqueous solution, sterile-filtered, suitable for cell culture
Sigma-Aldrich
胆固醇, from sheep wool, ≥92.5% (GC), powder
Sigma-Aldrich
DL-丙氨酸, ≥99% (HPLC)
Sigma-Aldrich
DL-丙氨酸, ≥99%, FCC, FG
SAFC
胆固醇, from sheep wool, Controlled origin, meets USP/NF testing specifications