Discovery of human-like L-asparaginases with potential clinical use by directed evolution.

Discovery of human-like L-asparaginases with potential clinical use by directed evolution.

Scientific reports (2017-09-02)

Coraline Rigouin, Hien Anh Nguyen, Amanda M Schalk, Arnon Lavie

摘要

L-asparaginase is a chemotherapy drug used to treat acute lymphoblastic leukemia (ALL). The main prerequisite for clinical efficacy of L-asparaginases is micromolar K

材料

Product Number

品牌

产品描述

G2751

Sigma-Aldrich

谷氨酸-草酰乙酸转氨酶来源于猪心脏, Type I, ammonium sulfate suspension, 200-500 units/mg protein

M2634

Sigma-Aldrich

苹果酸脱氢酶来源于猪心脏, buffered aqueous glycerol solution, 600-1000 units/mg protein (biuret)