HPLC Analysis of 3′,4′-Methylenedioxy-α-pyrrolidinopropiophenone (MDPPP) Enantiomers on Astec^® CHIROBIOTIC^® V2

Astec CHIROBIOTIC V2 15 cm x 4.6 mm I.D., 5 μm particles (15023AST)

[A] methanol; [B] water; [C] acetic acid; [D] ammonium hydroxide; (95:5:0.1:0.02, A:B:C:D)

1 mL/min

1100 psi (70 bar)

20 °C

UV, 251 nm

5 μL

100 μg/mL in methanol

3′,4′-Methylenedioxy-a-pyrrolidinopropiophenone, also known as MDPPP, is a synthetic cathinone found in numerous bath salt blends under the street name NRG-1. This designer drug first emerged in Germany in the late 1990s and early 2000s as an ingredient in imitation ecstasy pills. Astec CHIROBIOTIC V2, based on vancomycin CSP, provided resolution of the enatiomers. CRMs from Cerillliant provided reliable identification and quantification.

Astec is a registered trademark of Merck KGaA, Darmstadt, Germany, CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC