HPLC Analysis of Iloperidone and Hydroxy Iloperidone Using a Titan C18 Column
材料
used together
CONDITIONS
column
Titan C18, 10 cm x 3.0 mm I.D., 1.9 μm particles (577160-U)
mobile phase
[A] 10 mM ammonium formate; pH 3.0 with formic acid [B] 0.1% formic acid in methanol
gradient
45% B for 2 minutes followed by a linear gradient to 80% B for 10 minutes, followed by a hold at 80% B for 2 minutes.
flow rate
0.5 mL/min
pressure
6500 psi (445 bar)
column temp.
35 °C
detector
UV, 275 nm
injection
2 μL
sample
50 μg/mL and 5 μg/mL of hydroxy metabolite in 10% methanol
说明
分析说明
Iloperidone is an atypical antipsychotic administered for the treatment of schizophrenia. The drug is marketed under the trade names Fanapt® and Fanapta. Hydroxy iloperidone is a major metabolite of the atypical antipsychotic iloperidone which is administered for the treatment of schizophrenia. The metabolite is also pharmacologically active, possessing central nervous system (CNS) activity.
法律信息
Fanapt is a registered trademark of Vanda Pharmaceuticals
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