LC/MS/MS Analysis of Polymeric Isocyanates as Their MDI-DBA Derivatives on Ascentis® Express C18 after Collection using ASSET® EZ4-NCO Dry Sampler
CONDITIONS
sample preparation
Solvent Desorption
sample/matrix
ambient air
adsorbent tube
ASSET EZ4-NCO Dry Sampler (5028-U)
extraction
Contact Sigma-Aldrich Technical Services for extraction and full analytical protocol.
column
Ascentis Express C18, 5 cm x 2.1 mm I.D., 2 μm particles (50811-U)
mobile phase
[A] 95:5 (0.05% formic acid in water):(0.05% formic acid in acetonitrile); [B] 95:5 (0.05% formic acid in acetonitrile):(0.05% formic acid in water)
gradient
60% to 80% B in 2 min, held for 3 min, to 100% B in 0.1 min, held for 9.9 min, to 60% B in 0.1 min, held for 3.9 min
flow rate
0.4 mL/min
pressure
3626 psi (250 bar)
column temp.
35 °C
detector
MS/MS, ESI(+), MRM
injection
2.0 μL
sample
ASSET sampler filter spike, MDI monomer (7.37 μg/mL), MDI 3-ring oligomer (0.284 μg/mL), MDI 4-ring oligomer (0.912 μg/mL)
说明
分析说明
This application demonstrates the simultaneous analysis of dibutylamine derivatized isocyanate MDI monomer and oligomers.
其他说明
ASSET filters were spiked at various concentrations prior to extraction.
法律信息
Ascentis is a registered trademark of Merck KGaA, Darmstadt, Germany, Asset is a registered trademark of Merck KGaA, Darmstadt, Germany