12804
苯并三氮唑-N,N,N′,N′-四甲基脲六氟磷酸酯
≥98.0% (T), for peptide synthesis
别名:
N,N,N′,N′-四甲基-O-(1H-苯并三氮唑)六氟磷酸脲, HBTU
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关于此项目
经验公式（希尔记法）:
C11H16F6N5OP
化学文摘社编号:
分子量:
379.24
Beilstein:
7328329
EC 号:
MDL编号:
UNSPSC代码:
12352107
PubChem化学物质编号:
NACRES:
NA.22
产品名称
苯并三氮唑-N,N,N′,N′-四甲基脲六氟磷酸酯, ≥98.0% (T)
方案
≥98.0% (T)
表单
solid
反应适用性
reaction type: Coupling Reactions
mp
200 °C (dec.) (lit.)
溶解性
acetonitrile: 0.1 g/mL, clear
应用
peptide synthesis
官能团
amine
储存温度
2-8°C
SMILES字符串
F[P-](F)(F)(F)(F)F.CN(C)C(\On1nnc2ccccc12)=[N+](/C)C
InChI
1S/C11H16N5O.F6P/c1-14(2)11(15(3)4)17-16-10-8-6-5-7-9(10)12-13-16;1-7(2,3,4,5)6/h5-8H,1-4H3;/q+1;-1
InChI key
UQYZFNUUOSSNKT-UHFFFAOYSA-N
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一般描述
HBTU是一种肽偶联剂，用于基于Fmoc的固相肽合成。
应用
HBTU是用于多肽合成的多肽偶联剂。它也被用于标准Fmoc固相多肽合成（SPPS）方案。
最近研究显示，这种偶联试剂的结晶或溶液结构是胍的 N-氧化物形式，,而不是脲化合物； 用于多肽合成的偶联试剂；优点是：极低的外消旋化，简单的反应条件，非常短的反应时间和高产率。
警示用语：
Warning
危险声明
危险分类
Skin Sens. 1A
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
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Dengue virus (DENV) and West Nile virus (WNV) are mosquito-borne arboviruses responsible for causing acute systemic diseases and severe health conditions in humans. The discovery of therapies capable to prevent infections or treat infected individuals remains an important challenge, since
Structural studies of reagents for peptide bond formation: Crystal and molecular structures of HBTU and HATU.
Abdelmoty I, et al.
Lett. Pept. Sci., 1(2), 57-67 (1994)
Kaido Kurrikoff et al.
Scientific reports, 7(1), 17056-17056 (2017-12-08)
Non-viral gene delivery systems have gained considerable attention as a promising alternative to viral delivery to treat diseases associated with aberrant gene expression. However, regardless of extensive research, only a little is known about the parameters that underline in vivo
Hiroshi Wada et al.
PloS one, 13(7), e0199249-e0199249 (2018-07-04)
Recently, many autologous tumor antigens have been examined for their potential use in cancer immunotherapy. However, the success of cancer vaccines in clinical trials has been limited, partly because of the limitations of using single, short peptides in most attempts.
Mark Lommel et al.
Scientific reports, 8(1), 11753-11753 (2018-08-08)
Thrombospondins (TSPs) are multidomain glycoproteins with complex matricellular functions in tissue homeostasis and remodeling. We describe a novel role of TSP as a Wnt signaling target in the basal eumetazoan Hydra. Proteome analysis identified Hydra magnipapillata TSP (HmTSP) as a
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