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912220

Sigma-Aldrich

NanoFabTx™ PLGA-micro

for synthesis of 1-5 μm particles

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Synonym(s):
NanoFabTx™ reagent kit, PLGA microparticle kit

Quality Level

100

application(s)

advanced drug delivery

storage temp.

2-8°C

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General description

The NanoFabTx™ PLGA-micro kit provides reagents (PLGA and stabilizer) and a protocol for microfluidic synthesis of microparticles between 1 to 5 μm. This reagent kit can be combined with the NanoFabTx™ Microfluidic - micro device kit (Cat.No. 911860) for microfluidic synthesis of PLGA micro particles.

Application

NanoFabTx™ PLGA-micro for synthesis of 1-5 μm particle reagent kit is designed for the synthesis of hydrophobic drug- encapsulated poly(lactic-co-glycolic acid) (PLGA) microparticles. The protocol gives users step-by-step instructions developed and tested by our formulation scientists. The protocol includes suggested conditions for incorporating drugs into the formulation and details how to tailor the parameters to yield 1 μm particles, 5 μm particles, or any size in between—all with low polydispersity. This kit affords scientists the synthetic control and reproducibility needed to encapsulate drugs, proteins, or other molecules with polymer microparticles of a chosen size and drug loading. With this kit, researchers can quickly identify the ideal microparticle size and drug loading for their research application. PLGA is a biocompatible and biodegradable polymer that has been widely used in drug delivery systems for controlled drug release of many different types of therapeutic molecules.

Features and Benefits

  • Flexible synthesis tool to create uniform and reproducible nanoparticles
  • Optimized to make microparticles 1-5 μm by microfluidics with low polydispersity
  • Enables microparticle formulation screening and optimization of microparticles 1-5 μm to select ideal particle size for enhanced drug loading and controlled release
  • Based on non-toxic, biodegradable polymers

Legal Information

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 3

Regulatory Information

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Articles

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Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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