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912220

Sigma-Aldrich

NanoFabTx PLGA-micro

for synthesis of 1-5 μm particles

Synonym(s):

NanoFabTx reagent kit, PLGA microparticle kit

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About This Item

UNSPSC Code:
12161503
NACRES:
NA.23

To inquire about this product 912220, please contact your local Merck office or dealer. Contact Technical Service

Quality Level

application(s)

advanced drug delivery

storage temp.

2-8°C

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1 of 4

This Item
PHR3120S8502A5879
form

solid

form

-

form

powder

form

powder

assay

≥98% (HPLC)

assay

-

assay

≥98% (HPLC)

assay

≥98% (TLC)

Quality Level

100

Quality Level

300

Quality Level

200

Quality Level

100

solubility

water: 100 mg/mL, clear to very slightly hazy, colorless

solubility

-

solubility

H2O: 50 mg/mL

solubility

water: 50 mg/mL, clear to very slightly hazy, colorless to yellow

originator

Valeant

originator

-

originator

-

originator

-

Gene Information

human ... ACHE(43)

Gene Information

-

Gene Information

human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)

Gene Information

human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)

General description

The NanoFabTx PLGA-micro kit provides reagents (PLGA and stabilizer) and a protocol for microfluidic synthesis of microparticles between 1 to 5 μm. This reagent kit can be combined with the NanoFabTx Microfluidic - micro device kit (Cat.No. 911860) for microfluidic synthesis of PLGA micro particles.

Application

NanoFabTx PLGA-micro for synthesis of 1-5 μm particle reagent kit is designed for the synthesis of hydrophobic drug- encapsulated poly(lactic-co-glycolic acid) (PLGA) microparticles. The protocol gives users step-by-step instructions developed and tested by our formulation scientists. The protocol includes suggested conditions for incorporating drugs into the formulation and details how to tailor the parameters to yield 1 μm particles, 5 μm particles, or any size in between—all with low polydispersity. This kit affords scientists the synthetic control and reproducibility needed to encapsulate drugs, proteins, or other molecules with polymer microparticles of a chosen size and drug loading. With this kit, researchers can quickly identify the ideal microparticle size and drug loading for their research application. PLGA is a biocompatible and biodegradable polymer that has been widely used in drug delivery systems for controlled drug release of many different types of therapeutic molecules.

Features and Benefits

  • Flexible synthesis tool to create uniform and reproducible nanoparticles
  • Optimized to make microparticles 1-5 μm by microfluidics with low polydispersity
  • Enables microparticle formulation screening and optimization of microparticles 1-5 μm to select ideal particle size for enhanced drug loading and controlled release
  • Based on non-toxic, biodegradable polymers

Legal Information

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC

Storage Class Code

12 - Non Combustible Liquids

Regulatory Information

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