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Merck
CN

STAT3

signal transducer and activator of transcription 3 (acute-phase response factor)

别名:
APRF, HIES
物种:
UniProtKB ID:
基因ID:
  • Human(6774) Summary: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
  • Mouse(20848) signal transducer and activator of transcription 3
  • Rat(25125) signal transducer and activator of transcription 3 (acute-phase response factor)
  • naked mole-rat(101721899) signal transducer and activator of transcription 3 (acute-phase response factor)
  • domestic guinea pig(100717084) signal transducer and activator of transcription 3 (acute-phase response factor)
  • chicken(420027) signal transducer and activator of transcription 3 (acute-phase response factor)
  • Zebrafish(30767) signal transduction and activation of transcription 3
  • sheep(100294659) signal transducer and activator of transcription 3 (acute-phase response factor)
  • domestic cat(101095698) signal transducer and activator of transcription 3 (acute-phase response factor)
  • cow(508541) signal transducer and activator of transcription 3 (acute-phase response factor)
  • Horse(100052852) signal transducer and activator of transcription 3 (acute-phase response factor)
  • Domestic Rabbit(100348778) signal transducer and activator of transcription 3 (acute-phase response factor)
  • dog(490967) signal transducer and activator of transcription 3 (acute-phase response factor)
Antibodies

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Antibodies

Product Number
说明
物种反应性
应用
抗磷酸化STAT3(Tyr705)抗体,克隆9E12, clone 9E12, Upstate®, from mouse,
物种反应性
canine, human, mouse
应用
ELISA
immunoprecipitation (IP)

western blot
抗 磷酸化-STAT3 (pTyr 705 ) 兔抗, affinity isolated antibody,
物种反应性
human, mouse, rat
应用
immunohistochemistry
western blot
Anti-Stat3 Antibody, from rabbit,
物种反应性
bovine, human, mouse, pig, porcine, primate, rat
应用
immunoprecipitation (IP)
western blot
Anti-Phospho-Stat3-Y705 antibody produced in rabbit, ,
物种反应性
human, mouse, rat
应用
immunofluorescence
immunohistochemistry

western blot
Anti-Stat3 Antibody, clone 2D2 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
物种反应性
bovine, canine, feline, human, monkey, mouse, porcine, rat
应用
affinity binding assay
flow cytometry

immunocytochemistry

immunohistochemistry

western blot