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Merck
CN

903191

Benzyl 4-oxo-5-(triethylsilyl)-3,4-dihydropyridine-1(2H)-carboxylate

别名:

Garg silyl triflate precursor

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关于此项目

经验公式(希尔记法):
C19H27NO3Si
化学文摘社编号:
分子量:
345.51
UNSPSC Code:
12352005
Form:
liquid
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form

liquid

refractive index

n/D 1.548

density

1.079 g/mL

functional group

ketone, phenyl

storage temp.

−20°C

Application

Benzyl 4-oxo-5-(triethylsilyl)-3,4-dihydropyridine-1(2H)-carboxylate is a precursor to a Garg silyl triflate which upon exposure to fluoride generates a reactive azacyclic allene for cycloaddition reactions.


存储类别

10 - Combustible liquids

wgk

WGK 3

法规信息

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相关内容

The Garg group develops methods for the synthesis of natural products and pharmaceuticals. One key method pertains to heterocyclic arynes, such as indolynes and pyridynes, which are generated in situ from silyltriflate precursors under mild fluoride based reaction conditions.


Joyann S Barber et al.
Nature chemistry, 10(9), 953-960 (2018-08-01)
For over a century, the structures and reactivities of strained organic compounds have captivated the chemical community. Whereas triple-bond-containing strained intermediates have been well studied, cyclic allenes have received far less attention. Additionally, studies of cyclic allenes that bear heteroatoms