931853
SPhos Pd G6 acylation
≥95%, powder
别名:
(SPhos)Pd(4-CH2CH2CONHSPh)Br
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关于此项目
经验公式（希尔记法）:
C39H47BrNO6PPd
化学文摘社编号:
分子量:
843.09
MDL number:
NACRES:
NA.21
UNSPSC Code:
12352100
产品名称
SPhos Pd G6 acylation, ≥95%
product line
Buchwald precatalyst Generation 6
Quality Level
assay
≥95%
form
powder
reaction suitability
reagent type: catalyst
reaction type: Cross Couplings
greener alternative product characteristics
Catalysis
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General description
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Application
SPhos Pd G6 acylation is an oxidative addition complex (OAC) of SPhos for use in bioconjugation. The pendant NHS-functional group allows coupling to protein amines through a selective acylation. The protein-OAC can then be reacted with a second, cysteine-containing protein. This facile approach allows for protein homodimerization as well as the formation of antibody-protein conjugates.
Learn more about G6 Buchwald precatalysts
Learn more about G6 Buchwald precatalysts
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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Buchwald G6 precatalysts are oxidative addition complexes that are thermally, air, and moisture stable. The catalyst activation doesn’t require a base and generates innocuous byproducts.
Muhammad Jbara et al.
Angewandte Chemie (International ed. in English), 60(21), 12109-12115 (2021-03-18)
Organometallic reagents enable practical strategies for bioconjugation. Innovations in the design of water-soluble ligands and the enhancement of reaction rates have allowed for chemoselective cross-coupling reactions of peptides and proteins to be carried out in water. There are currently no
Heemal H Dhanjee et al.
Journal of the American Chemical Society, 142(51), 21237-21242 (2020-12-16)
Palladium oxidative addition complexes (OACs) are traditionally accessed by treating an aryl halide-containing substrate with a palladium(0) source. Here, a new strategy to selectively prepare stable OACs from amino groups on native proteins is presented. The approach relies on an
Ryan P King et al.
Organic letters, 23(20), 7927-7932 (2021-10-07)
The utilization of isolated Palladium Oxidative Addition Complexes (OACs) has had a significant impact on Pd-catalyzed and Pd-mediated cross-coupling reactions. Despite their importance, widespread utility of OACs has been limited by the instability of their precursor complexes. Herein, we report
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 931853-100MG | 04065269059400 |