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文件

COA分析证书/COQ

AB2255

抗-GABA B受体R2抗体

Name: 抗-GABA B受体R2抗体
Brand: MM

serum, from guinea pig

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别名:

G protein-coupled receptor 51, G-protein coupled receptor 51, GABA-B receptor 2, gamma-aminobutyric acid (GABA) B receptor, 2, gamma-aminobutyric acid B receptor, 2, GABA-B-R2, GABA(B)R2

eCl@ss:

32160702

NACRES:

NA.41

生物来源

guinea pig

质量水平

100

抗体形式

serum

抗体产品类型

primary antibodies

克隆

polyclonal

种属反应性

rhesus macaque, rat

种属反应性（根据同源性预测）

canine (based on 100% sequence homology), bovine (based on 100% sequence homology), human (based on 100% sequence homology), horse (based on 100% sequence homology), rhesus monkey (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), mouse (based on 100% sequence homology)

技术

immunohistochemistry: suitable
western blot: suitable

NCBI登记号

NP_113990

UniProt登记号

O88871

运输

wet ice

靶向翻译后修饰

unmodified

基因信息

human ... GABBR2(9568)

一般描述

γ-氨基丁酸（GABA）是哺乳动物中枢神经紧张的系统中主要的抑制性神经递质。GABA通过离子型[GABA（A/C）]受体发挥其作用，以产生快速的突触抑制，而代谢型[GABA（B）]受体则产生缓慢，延长的抑制信号。GABA（B）受体由两个相关的7跨膜受体GABA（B）受体1和GABA（B）受体2的异二聚体组成。GABA（B）受体1基因被定位到靠近HLA-F基因的HLA I类区域内的染色体6p21.3。多发性硬化、癫痫和精神分裂症的易感基因座也已定位于该区域。该基因的可变剪接产生4个转录物变体。

特异性

该抗体可识别大鼠GABA-B-R2的C端。

免疫原

在大鼠GABA-B-R2的C末端的牛甲状腺球蛋白偶联的线性肽。

应用

抗GABAB受体R2抗体是用于IH & WB的抗GABAB受体R2的抗体。

质量

通过免疫组化对大鼠中脑区浦肯野细胞进行了评估。

免疫组化分析：该抗体的1:300稀释液在大鼠中脑区域的浦肯野细胞中检测到GABA-B-R2。

目标描述

尽管在计算的105 kDa分子量周围观察到一条条带，但由于该条带与存在的其他非特异性条带相比较弱，因此该抗体不推荐使用蛋白质印迹法。

联系

替代品：AB5394

分析说明

对照
大鼠中脑区的浦肯野细胞

储存分类代码

12 - Non Combustible Liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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