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PHR1393

三水合氨苄青霉素

Name: 三水合氨苄青霉素
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

氨苄西林三水合物, 氨苄青霉素

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关于此项目

经验公式（希尔记法）:

C₁₆H₁₉N₃O₄S · 3H₂O

化学文摘社编号:

7177-48-2

分子量:

403.45

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329823367

EC Number:

200-709-7

Beilstein/REAXYS Number:

5399534

MDL number:

MFCD00072036

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属性

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

USP 1033000/1033407, traceable to Ph. Eur. A1000000

API family

ampicillin

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

198-200 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

O.O.O.CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccccc3)C(=O)N2[C@H]1C(O)=O

InChI

1S/C16H19N3O4S.3H2O/c1-16(2)11(15(22)23)19-13(21)10(14(19)24-16)18-12(20)9(17)8-6-4-3-5-7-8;;;/h3-7,9-11,14H,17H2,1-2H3,(H,18,20)(H,22,23);3*1H2/t9-,10-,11+,14-;;;/m1.../s1

InChI key

RXDALBZNGVATNY-CWLIKTDRSA-N

说明

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Ampicillin trihydrate may be used as an analytical reference standard for the determination of ampicillin in plasma samples and pharmaceutical formulations by chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

一种具有连接到青霉素结构上的氨基侧链的 β-内酰胺抗生素。通过灭活细菌细胞膜内表面的转肽酶而抑制细菌细胞壁合成（肽聚糖交联）的青霉素衍生物。仅对生长中的大肠埃希菌具有杀菌作用。耐药方式：氨苄西林的 β-内酰胺环被 β-内酰胺酶裂解。抗菌谱：革兰阴性菌和革兰阳性菌。

Other Notes

To see an example of a Certificate of Analysis for this material enter LRAA1900 in the slot below. This is an example certificate only and may not be the lot that you receive.

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pictograms

GHS08,GHS07

signalword

Danger

hcodes

H315,H317,H319,H334,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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Determination of ampicillin in human plasma by high-performance liquid chromatography using ultraviolet detection.

Akhtar MJ, et al.

Journal of Pharmaceutical and Biomedical Analysis, 11(4-5), 375-378 (1993)

Determination of amoxicillin, ampicillin, and penicillin G using a flow injection analysis method with chemiluminescence detection.

Chivulescu AI, et al.

Rev. Roum. Chim., 56(3), 247-254 (2011)

Adjunctive corticosteroid therapy improves lung immunopathology and survival during severe secondary pneumococcal pneumonia in mice.

Hazem E Ghoneim et al.

The Journal of infectious diseases, 209(9), 1459-1468 (2013-11-26)

Secondary bacterial pneumonia is a significant cause of morbidity and mortality during influenza, despite routine use of standard antibiotics. Antibiotic-induced immunopathology associated with bacterial cell wall lysis has been suggested to contribute to these poor outcomes. Using Streptococcus pneumoniae in

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全球贸易项目编号

货号	GTIN
PHR1393-1G	04061834416258