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PHR1720

氯米帕明

Name: 氯米帕明
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

氯米帕明盐酸盐

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关于此项目

经验公式（希尔记法）:

C₁₉H₂₃ClN₂ · HCl

化学文摘社编号:

17321-77-6

分子量:

351.31

NACRES:

NA.24

PubChem Substance ID:

329823573

UNSPSC Code:

41116107

EC Number:

241-344-3

MDL number:

MFCD00069234

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属性

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. C2360000, traceable to USP 1140427

API family

clomipramine

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Cl.CN(C)CCCN1c2ccccc2CCc3ccc(Cl)cc13

InChI

1S/C19H23ClN2.ClH/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22;/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3;1H

InChI key

WIMWMKZEIBHDTH-UHFFFAOYSA-N

Gene Information

human ... SLC6A4(6532)

说明

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Clomipramine hydrochloride is one of the dibenzazepine tricyclic antidepressants that inhibits noradrenalin and serotonin reuptake in central nervous system. It also shows antimuscarinic properties.

Application

Clomipramine hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in traditional Chinese medicine and pharmaceutical formulations by analytical and cyclodextrin-modified capillary zone electrophoresis techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAC3902 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

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pcodes

P260 - P264 - P271 - P273 - P301 + P312 - P308 + P311

pictograms

GHS08,GHS07,GHS09

signalword

Danger

hcodes

H302,H336,H370,H410

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT SE 1 - STOT SE 3

target_organs

Central nervous system, Central nervous system,Cardiovascular

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

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Method for simultaneous determination of eight cyclic antidepressants by cyclodextrin-modified capillary zone electrophoresis: applications in pharmaceuticals.

Kou HS, et al.

Analytica Chimica Acta, 525(1), 23-30 (2004)

Multicommutated flow system for the chemiluminometric determination of clomipramine in pharmaceutical preparations.

Marques KL, et al.

Analytica Chimica Acta, 518(1-2), 31-36 (2004)

HPLC and GC?MS screening of Chinese proprietary medicine for undeclared therapeutic substances.

Liu SY, et al.

Journal of Pharmaceutical and Biomedical Analysis, 24(5-6), 983-992 (2001)

全球贸易项目编号

货号	GTIN
PHR1720-1G	04061834802006