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Y0000705

米氮平

Name: 米氮平
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

别名:

1,2,3,4,10,14b-Hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3-c][2]benzazepine

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关于此项目

经验公式（希尔记法）:

C₁₇H₁₉N₃

化学文摘社编号:

85650-52-8

分子量:

265.35

NACRES:

NA.24

PubChem Substance ID:

329831107

UNSPSC Code:

41116107

MDL number:

MFCD00865427

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属性

grade

pharmaceutical primary standard

API family

mirtazapine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

CN1CCN2C(C1)c3ccccc3Cc4cccnc24

InChI

1S/C17H19N3/c1-19-9-10-20-16(12-19)15-7-3-2-5-13(15)11-14-6-4-8-18-17(14)20/h2-8,16H,9-12H2,1H3

InChI key

RONZAEMNMFQXRA-UHFFFAOYSA-N

Gene Information

human ... ADRA2A(150), ADRA2B(151), ADRA2C(152), HTR2A(3356), HTR2C(3358)

说明

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Mirtazapine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Mirtazapine is a noradrenergic and specific serotonergic antidepressant (NaSSA). Mirtazapine agonizes selective adrenergic and serotonergic receptors so that both NE release and 5-HT_1A mediated serotonergic signaling are increased.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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pictograms

GHS07

signalword

Warning

hcodes

H302,H336

pcodes

P261 - P264 - P270 - P271 - P301 + P312 - P304 + P340 + P312

Hazard Classifications

Acute Tox. 4 Oral - STOT SE 3

target_organs

Central nervous system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Evaluation of 5-HT2A and mGlu2/3 receptors in postmortem prefrontal cortex of subjects with major depressive disorder: effect of antidepressant treatment.

Carolina Muguruza et al.

Neuropharmacology, 86, 311-318 (2014-08-26)

Several studies have demonstrated alterations in serotonin 5-HT2A (5-HT2AR) and glutamate metabotropic mGlu2 (mGlu2R) receptors in depression, but never in the same sample population. Recently it has been shown that both receptors form a functional receptor heterocomplex that is altered

Interaction of 5-HTT and HTR1A gene polymorphisms in treatment responses to mirtazapine in patients with major depressive disorder.

Hun Soo Chang et al.

Journal of clinical psychopharmacology, 34(4), 446-454 (2014-06-10)

We tested for the association of HTR1A and 5-HTT genetic polymorphisms with treatment response to mirtazapine and evaluated the interactive effect between the polymorphisms in 283 patients with major depressive disorder. Korean subjects with diagnosis of major depressive disorder using

The effect of risperidone on the mirtazapine-induced changes in extracellular monoamines in the rat frontal cortex.

Katarzyna Kamińska et al.

Pharmacological reports : PR, 66(6), 984-990 (2014-12-03)

The aim of our study was to understand the mechanism of clinical efficacy of the combination of an antidepressant and risperidone in drug-resistant depression. We studied the effect of an antidepressant (mirtazapine) and risperidone (atypical antipsychotic), given separately or jointly

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货号	GTIN
Y0000705	04061833796252