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A0325200

Alcuronium chloride

Name: Alcuronium chloride
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

别名:

N,N′-Diallylnortoxiferinium dichloride

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关于此项目

经验公式（希尔记法）:

C₄₄H₅₀Cl₂N₄O₂

化学文摘社编号:

15180-03-7

分子量:

737.80

MDL number:

MFCD01711239

UNSPSC Code:

41116107

NACRES:

NA.24

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属性

grade

pharmaceutical primary standard

API family

alcuronium

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

−20°C

SMILES string

[Cl-].[Cl-].[N+]21([C@@H]3C4([C@H]5N(c%11c4cccc%11)\C=C6/[C@@H]7N(c8c(cccc8)C97[C@H]%10[N+](CC9)(C\C(=C\CO)\C/6C%10)CC=C)\C=C/5\C(C3)\C(=C/CO)\C2)CC1)CC=C

InChI

1S/C44H50N4O2.2ClH/c1-3-17-47-19-15-43-35-9-5-7-11-37(35)45-26-34-32-24-40-44(16-20-48(40,18-4-2)28-30(32)14-22-50)36-10-6-8-12-38(36)46(42(34)44)25-33(41(43)45)31(23-39(43)47)29(27-47)13-21-49;;/h3-14,25-26,31-32,39-42,49-50H,1-2,15-24,27-28H2;2*1H/q+2;;/p-2/b29-13-,30-14-,33-25-,34-26-;;/t31?,32?,39-,40-,41-,42-,43?,44?,47?,48?;;/m0../s1

InChI key

CPYGBGOXCJJJGC-ZHNYPADJSA-L

说明

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Alcuronium chloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

pictograms

GHS06

signalword

Danger

hcodes

H300

pcodes

P301 + P330 + P331 + P310

Hazard Classifications

Acute Tox. 2 Oral

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

涉药品监管产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Changes of cooperativity between N-methylscopolamine and allosteric modulators alcuronium and gallamine induced by mutations of external loops of muscarinic M(3) receptors.

A Krejcí et al.

Molecular pharmacology, 60(4), 761-767 (2001-09-20)

To clarify the involvement of specific domains of muscarinic receptors in the action of allosteric modulators, muscarinic M(3) receptors (on which allosteric interactions are weak) were genetically modified to become more similar to M(2) receptors (on which allosteric interactions are

G-protein coupled receptors as allosteric machines.

Terry Kenakin

Receptors & channels, 10(2), 51-60 (2004-06-19)

Allosterism, whereby small molecule ligands produce global changes in the conformations of receptors, is a powerful mechanism for drug effect. This is illustrated by the recent data describing CCR5 antagonists as blockers of HIV infection. Allosteric effects are described in

Allosteric interactions at muscarinic cholinoceptors.

A Christopoulos et al.

Clinical and experimental pharmacology & physiology, 25(3-4), 185-194 (1998-05-20)

1. An allosteric interaction occurs when the binding of a ligand to its site on a receptor is able to modify the binding of another ligand to a topographically distinct site on the same receptor and vice versa. The muscarinic

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全球贸易项目编号

货号	GTIN
A0325200	04061833327432