A0363000
盐酸金刚烷胺 盐酸盐
European Pharmacopoeia (EP) Reference Standard
别名:
1-氨基金刚烷 盐酸盐, 1-金刚烷胺 盐酸盐, NSC 83653, 三环[3.3.1.1 3,7 ] 癸烷-1-胺 盐酸盐
等级
pharmaceutical primary standard
API类
amantadine
制造商/商品名称
EDQM
应用
pharmaceutical (small molecule)
包装形式
neat
储存温度
2-8°C
SMILES字符串
Cl[H].[H][C@@]12C[C@@]3([H])C[C@@]([H])(C1)CC(N)(C2)C3
InChI
1S/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H/t7-,8+,9-,10-;
InChI key
WOLHOYHSEKDWQH-SOVZANNPSA-N
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一般描述
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
应用
Amantadine hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
生化/生理作用
多巴胺释放剂用于治疗帕金森综合征和药物引起的锥体外系反应。
包装
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
其他说明
Sales restrictions may apply.
警示用语：
Warning
危险声明
预防措施声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
S Ito et al.
Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 38(12), 897-902 (2001-03-14)
A virus infection was studied using half of the normal oral dose of amantadine hydrochloride-100 mg/d instead of 200 mg/d. The patients in this study, who visited the clinics during January and February 1999, were confirmed within 48 hours to
F Y Aoki et al.
Clinical pharmacokinetics, 14(1), 35-51 (1988-01-01)
Amantadine is a drug with diverse uses ranging from prevention of influenza A illness to the treatment of patients with Parkinson's disease. It is available only in oral formulations from which it is well absorbed and widely distributed, little drug
Amantadine hydrochloride: current and new uses.
S de Roin et al.
The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses, 22(5), 322-325 (1990-10-01)
Matias Rey-Carrizo et al.
Journal of medicinal chemistry, 57(13), 5738-5747 (2014-06-19)
Amantadine inhibits the M2 proton channel of influenza A virus, yet most of the currently circulating strains of the virus carry mutations in the M2 protein that render the virus amantadine-resistant. While most of the research on novel amantadine analogues
Bo OuYang et al.
Biochimica et biophysica acta, 1838(4), 1058-1067 (2013-09-24)
Many viral genomes encode small, integral membrane proteins that form homo-oligomeric channels in membrane, and they transport protons, cations, and other molecules across the membrane barrier to aid various steps of viral entry and maturation. These viral proteins, collectively named
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