产品名称
氨苯砜, European Pharmacopoeia (EP) Reference Standard
InChI key
MQJKPEGWNLWLTK-UHFFFAOYSA-N
SMILES string
Nc1ccc(cc1)S(=O)(=O)c2ccc(N)cc2
InChI
1S/C12H12N2O2S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8H,13-14H2
grade
pharmaceutical primary standard
agency
EP Reference Standard
API family
dapsone
manufacturer/tradename
EDQM
mp
175-177 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
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Application
Dapsone EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Other Notes
Sales restrictions may apply.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
signalword
Danger
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 2 - Repr. 1B - STOT RE 2 - STOT SE 2
target_organs
Blood, Blood,spleen,Liver
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Noah Scheinfeld
Current opinion in investigational drugs (London, England : 2000), 10(5), 474-481 (2009-05-12)
Allergen Inc has launched Aczone, a topical gel formulation of the antibacterial, anti-inflammatory agent dapsone, for the potential treatment of acne vulgaris. Oral dapsone has demonstrated efficacy in acne, but was associated with severe side effects such as anemia, which
Hakan M Gürcan et al.
American journal of clinical dermatology, 10(6), 383-396 (2009-10-15)
Dapsone is a chemotherapeutic agent primarily used in treating leprosy, Pneumocystis jiroveci (previously carinii) pneumonia, and malaria. It is also used as an adjuvant in the treatment of pemphigus and pemphigoid. To assess the role of dapsone in the treatment
Richard E Kast et al.
Anti-cancer agents in medicinal chemistry, 11(8), 756-761 (2011-06-29)
Data from past research is presented showing that neutrophils are active participants in new vessel formation in normal physiology, in proliferating human endometrium, in non-cancer pathologies as in the pannus of rheumatoid arthritis, and in various cancers, among them glioblastoma.
Mira Stotland et al.
American journal of clinical dermatology, 10(4), 221-227 (2009-06-06)
Dapsone, a synthetic sulfone that has been available for over 60 years, has been used to treat a myriad of cutaneous disorders. Prior to the general acceptance of isotretinoin, oral dapsone had been reported to be effective in the treatment
Maria Lorenz et al.
Acta dermato-venereologica, 92(2), 194-199 (2012-02-07)
Dapsone is widely used in the treatment of leprosy and several chronic inflammatory dermatological conditions. Hypersensitivity reactions to dapsone are potentially fatal adverse drug reactions with unknown prevalence and risk factors. We performed a systematic review covering all reported cases
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