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文件

F0005000

法莫替丁

Name: 法莫替丁
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

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别名:

法莫替丁, N′-（氨基磺酰基）-3-([2-（二氨基亚甲基氨基）-4-噻唑基]甲硫基)丙脒

经验公式（希尔记法）:

C₈H₁₅N₇O₂S₃

CAS号:

76824-35-6

分子量:

337.45

MDL编号:

MFCD00079297

PubChem化学物质编号:

329799617

NACRES:

NA.24

生物来源

synthetic

等级

pharmaceutical primary standard

Agency

EP Reference Standard

API类

famotidine

形式

solid

包装

pkg of 110 mg

制造商/商品名称

EDQM

储存条件

protect from light

应用

pharmaceutical (small molecule)

格式

neat

运输

ambient

储存温度

2-8°C

SMILES字符串

N\C(N)=N\c1nc(CSCCC(=N)NS(N)(=O)=O)cs1

InChI

1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)

InChI key

XUFQPHANEAPEMJ-UHFFFAOYSA-N

基因信息

human ... HRH2(3274)

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一般描述

Famotidine is a hydrophilic, cationic, histamine H2 receptor antagonist drug that effectively inhibits gastric acid secretion in humans.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

应用

This European Pharmacopoeia reference standard is intended for use only as specifically prescribed in the European Pharmacopoeia.

生化/生理作用

H₂组胺受体拮抗剂；抗溃疡剂。

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

1269243

1269265

1269221

1269232

1269254

BP653

法莫替丁, British Pharmacopoeia (BP) Reference Standard

PHR2908

PHR2909

PHR2910

Famotidine Related Compound C

PHR2911

Famotidine Related Compound D

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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示例

T1503

货号

25G

包装规格/数量

其它示例：

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

输入内容 1.000309185)

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索取COA

Famotidine

European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare

European pharmacopoeia, 29(1-2), 2609-2610 (2017)

Determination of famotidine in acid reduction tablets by HPTLC and videodensitometry of fluorescence quenched zones

Campbell AN and Sherma J

Journal of Liquid Chromatography and Related Technologies, 26(16), 2719-2727 (2003)

Determination of cimetidine, famotidine, and ranitidine hydrochloride in the presence of their sulfoxide derivatives in pure and dosage forms by high-performance thin-layer chromatography and scanning densitometry

Kelani KM, et al.

Journal of AOAC (Association of Official Analytical Chemists) International, 85(5), 1015-1020 (2002)

Stability indicating method for famotidine in pharmaceuticals using porous graphitic carbon column

Helali N and Monser L

Journal of Separation Science, 31(2) (2008)

Pharmacokinetics and pharmacodynamics of famotidine in paediatric patients.

L P James et al.

Clinical pharmacokinetics, 31(2), 103-110 (1996-08-01)

Famotidine, an H2 receptor antagonist, has several potential advantages over cimetidine and ranitidine. These advantages include its potency, relatively longer elimination half-life, and lack of interaction with the cytochrome P450 isoforms. Eight studies addressing the use of famotidine in paediatric

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