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Merck
CN

L0376000

Leuprorelin

European Pharmacopoeia (EP) Reference Standard

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关于此项目

经验公式（希尔记法）:
C59H84N16O12
化学文摘社编号:
53714-56-0
分子量:
1209.40
UNSPSC Code:
41116107
NACRES:
NA.24

主要文件

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SMILES string

[nH]1cncc1C[C@H](NC(=O)C6NC(=O)CC6)C(=O)N[C@@H](Cc4c5c([nH]c4)cccc5)C(=O)NC(CO)C(=O)N[C@@H](Cc3ccc(cc3)O)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2[C@@H](CCC2)C(=O)NCC.OC(=O)C

InChI

1S/C57H80N16O12.C2H4O2/c1-6-61-53(82)44-14-10-22-73(44)56(85)39(13-9-21-62-57(58)59)66-54(83)46(30(2)3)72-55(84)47(31(4)5)71-51(80)40(23-32-15-17-35(75)18-16-32)67-52(81)43(28-74)70-49(78)41(24-33-26-63-37-12-8-7-11-36(33)37)68-50(79)42(25-34-27-60-29-64-34)69-48(77)38-19-20-45(76)65-38;1-2(3)4/h7-8,11-12,15-18,26-27,29-31,38-44,46-47,63,74-75H,6,9-10,13-14,19-25,28H2,1-5H3,(H,60,64)(H,61,82)(H,65,76)(H,66,83)(H,67,81)(H,68,79)(H,69,77)(H,70,78)(H,71,80)(H,72,84)(H4,58,59,62);1H3,(H,3,4)/t38?,39-,40-,41-,42-,43?,44-,46-,47+;/m0./s1

InChI key

ATCUBNJYGKGZGL-GZROYGCLSA-N

grade

pharmaceutical primary standard

API family

leuprorelin

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

相关类别

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, has been developed and issued under the Authority of the Issuing Pharmacopoeia.

For further information and support please go to the website of the issuing Pharmacopoeia.

It is a synthetic nonapeptide analogue of the hypothalamic peptide, gonadorelin. It is obtained by chemical synthesis and is available as an acetate.

Application

This European Pharmacopoeia reference standard is intended for use only as specifically prescribed in the European Pharmacopoeia. Their suitability for any other use is not guaranteed and is the sole responsibility of the user. This standard is not intended for human or animal use.
Established for the preparation of reference solutions (a) in the assay and testing of related substances of leuprorelin using liquid chromatography (General text 2.2.29), according to the monograph 1442 of European Pharmacopeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

监管及禁止进口产品
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分析证书(COA)

Lot/Batch Number

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Piero Periti et al.
Clinical pharmacokinetics, 41(7), 485-504 (2002-06-27)
Leuprorelin acetate is a synthetic agonist analogue of gonadotropin-releasing hormone. Continued leuprorelin administration results in suppression of gonadal steroid synthesis, resulting in pharmacological castration. Since leuprorelin is a peptide, it is orally inactive and generally given subcutaneously or intramuscularly. Sustained
R Berges et al.
Current medical research and opinion, 22(4), 649-655 (2006-05-11)
Leuprorelin is a well known luteinising hormone releasing hormone (LHRH) agonist. The drug is effective in the treatment of advanced prostate cancer and is well tolerated. This article reviews published literature (based on a search of PubMed, EMBASE and Biosis
Leuprorelin
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 3073-3074 (2008)
Michael T Schweizer et al.
Cancer, 119(20), 3610-3618 (2013-08-15)
The current trial evaluated 2 common therapies for patients with advanced prostate cancer, docetaxel and hormonal therapy (HT), in the surgical adjuvant setting. TAX-3501 was a randomized, phase 3, adjuvant study post-radical prostatectomy (RP) in high-risk patients with prostate cancer
Gina Lama et al.
PloS one, 8(1), e52530-e52530 (2013-01-18)
High cell-surface GnRH receptor (GnRH-R) levels have been shown to have a major influence on the extent of GnRH agonist-mediated tumor growth inhibition. The ability of the GnRH agonist leuprorelin acetate (LA) to induce a post-transcriptional upregulation of GnRH-R at
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