InChI
1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)
SMILES string
OC(=O)c1cccnc1
InChI key
PVNIIMVLHYAWGP-UHFFFAOYSA-N
biological source
synthetic
grade
pharmaceutical primary standard
agency
EP
API family
nicotinic acid
form
solid
manufacturer/tradename
EDQM
technique(s)
gas chromatography (GC): suitable, liquid chromatography (LC): suitable
mp
236-239 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
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General description
Nicotinic acid is a type of vitamin B that is effective against dyslipidemia. It can also be potentially used as a peripheral vasodilator.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Nicotinic acid may be used as an EP reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Other Notes
Sales restrictions may apply.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
379.4 °F - closed cup
flash_point_c
193 °C - closed cup
Development and optimisation of a generic micellar electrokinetic capillary chromatography method to support analysis of a wide range of pharmaceuticals and excipients
Altria KD and McLean R
Journal of Pharmaceutical and Biomedical Analysis, 18(4-5), 807-813 (1998)
Nicotinic acid
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 5(2), 4961-4962 (2017)
Simultaneous Estimation of Meclizine Hydrochloride and Nicotinic Acid in Pharmaceutical Dosage form by RP-HPLC Method
REDDY S, et al.
Asian Journal of Pharmaceutical Research and Health Care, 5(2) (2013)
RP-HPLC method for the determination of atorvastatin calcium and nicotinic acid in combined tablet dosage form
Shah DA, et al.
Indian Journal of Pharmaceutical Sciences, 69(5), 700-700 (2007)
Janet E Digby et al.
Current opinion in lipidology, 20(4), 321-326 (2009-06-06)
Nicotinic acid is the most potent treatment clinically available for lowering LDL cholesterol and VLDL cholesterol and raising HDL cholesterol. The strong inverse relationship between coronary heart disease risk and HDL cholesterol at all levels of LDL cholesterol has, therefore
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