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经验公式（希尔记法）:
C17H19N3O4S
化学文摘社编号:
分子量:
361.42
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
8347309
产品名称
奥美拉唑杂质D, European Pharmacopoeia (EP) Reference Standard
InChI
1S/C17H19N3O4S/c1-10-8-18-15(11(2)16(10)24-4)9-25(21,22)17-19-13-6-5-12(23-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)
SMILES string
O=S(C1=NC2=CC(OC)=CC=C2N1)(CC3=NC=C(C)C(OC)=C3C)=O
InChI key
IXEQEYRTSRFZEO-UHFFFAOYSA-N
grade
pharmaceutical primary standard
API family
omeprazole
manufacturer/tradename
EDQM
application(s)
pharmaceutical (small molecule)
format
neat
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Application
Omeprazole impurity D EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Other Notes
Sales restrictions may apply.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 2
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
W Tassaneeyakul et al.
British journal of clinical pharmacology, 49(2), 139-144 (2000-02-15)
To determine the effect of grapefruit juice on omeprazole metabolism in vivo. This was a randomized crossover study with a 2 week washout period. Omeprazole (20 mg) was taken orally by 13 healthy volunteers after an overnight fast with either
Y Shu et al.
The Journal of pharmacology and experimental therapeutics, 295(2), 844-851 (2000-10-25)
It has been previously reported that omeprazole (OP) oxidation is mediated by CYP2C19 and CYP3A4 in human livers. In this study, we assessed their relative contributions with human liver microsomal fractions from Chinese populations that were genotyped by CYP2C19 and
D S Yim et al.
Journal of chromatography. B, Biomedical sciences and applications, 754(2), 487-493 (2001-05-08)
A column-switching system based on semi-microcolumns was used for direct analysis of omeprazole and omeprazole sulfone in human plasma samples. Plasma samples were injected into a mixed-function (MF Ph-1) column (35 mmx4.6 mm I.D.) to remove proteins and other non-specific
A Abelö et al.
Drug metabolism and disposition: the biological fate of chemicals, 28(8), 966-972 (2000-07-20)
This study demonstrates the stereoselective metabolism of the optical isomers of omeprazole in human liver microsomes. The intrinsic clearance (CL(int)) of the formation of the hydroxy metabolite from S-omeprazole was 10-fold lower than that from R-omeprazole. However, the CL(int) value
Ia Hultman et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 848(2), 317-322 (2006-12-05)
A LC-MS/MS method was developed for quantitative determination of esomeprazole, and its two main metabolites 5-hydroxyesomeprazole and omeprazole sulphone in 25 microL human, rat or dog plasma. The analytes and their internal standards were extracted from plasma into methyl tert-butyl
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