PHR1179
氯噻嗪
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
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关于此项目
经验公式（希尔记法）:
C7H6ClN3O4S2
化学文摘社编号:
分子量:
295.72
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
200-404-9
MDL number:
产品名称
氯噻嗪, Pharmaceutical Secondary Standard; Certified Reference Material
InChI
1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13)
InChI key
JBMKAUGHUNFTOL-UHFFFAOYSA-N
SMILES string
O=S(C1=C2C=C(Cl)C(S(N)(=O)=O)=C1)(NC=N2)=O
grade
certified reference material
pharmaceutical secondary standard
agency
traceable to Ph. Eur. C1700000
traceable to USP 1121005
API family
chlorothiazide
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
Quality Level
Gene Information
human ... SLC12A3(6559)
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Analysis Note
These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.
Application
Chlorothiazide may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography.
One of the first in the thiazide class of diuretics.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
General description
Chlorothiazide belongs to the class of thiazide diuretic drugs. It is used for the management of postparturient udder edema in cattle. Its mode of action involves the inhibition of chloride reabsorption in the proximal portion of distal tubule.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA8998 in the slot below. This is an example certificate only and may not be the lot that you receive.
signalword
Danger
hcodes
Hazard Classifications
Resp. Sens. 1 - Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
监管及禁止进口产品
此项目有
Chlorothiazide
USP42-NF37: United States Pharmacopeia and National Formulary
United States Pharmacopeia/National Formulary, 29(5), 942-942 (2019)
Pharmacologic Adjuncts I
Assisted Ventilation of the Neonate, 311-328 (2003)
Liquid chromatography in pharmaceutical analysis II: Determination of a reserpine?chlorothiazide mixture
Honigberg IL, et al.
Journal of Pharmaceutical Sciences, 63(11), 1762-1764 (1974)
Validated micellar electrokinetic capillary chromatography method for quality control of the drug substances hydrochlorothiazide and chlorothiazide
Thomas BR, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 657(2), 383-394 (1994)
Liquid chromatographic determination of chlorothiazide and hydrochlorothiazide diuretic drugs in bovine milk
Shaikh B and Rummel N
Journal of Agricultural and Food Chemistry, 46(3), 1039-1043 (1998)
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