PHR1300
地喹氯铵
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
1,1′-Decamethylenebis(4-aminoquinaldinium) dichloride
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关于此项目
经验公式（希尔记法）:
C30H40Cl2N4
化学文摘社编号:
分子量:
527.57
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
208-330-9
MDL number:
InChI key
LTNZEXKYNRNOGT-UHFFFAOYSA-N
InChI
1S/C30H38N4.2ClH/c1-23-21-27(31)25-15-9-11-17-29(25)33(23)19-13-7-5-3-4-6-8-14-20-34-24(2)22-28(32)26-16-10-12-18-30(26)34;;/h9-12,15-18,21-22,31-32H,3-8,13-14,19-20H2,1-2H3;2*1H
SMILES string
[Cl-].[Cl-].Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]3c(C)cc(N)c4ccccc34
grade
certified reference material, pharmaceutical secondary standard
agency
traceable to Ph. Eur. D0430000
API family
dequalinium
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
mp
≥300 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
Quality Level
General description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Dequalinium chloride (DECA) is a cationic, lipophilic mitochondrial toxin which can act as a cyctotoxic agent on the mitochondrial membrane of specific epithelial carcinoma cells, by inhibiting the cellular energy production. It can have useful applications in cancer therapy.
Dequalinium chloride (DECA) is a cationic, lipophilic mitochondrial toxin which can act as a cyctotoxic agent on the mitochondrial membrane of specific epithelial carcinoma cells, by inhibiting the cellular energy production. It can have useful applications in cancer therapy.
Application
Dequalinium chloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by high performance liquid chromatography (HPLC).
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Analysis Note
These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.
Other Notes
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC3331 in the slot below. This is an example certificate only and may not be the lot that you receive.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Toxicity of the mitochondrial poison dequalinium chloride in a murine model system
Gamboa-Vujicic G, et al.
Journal of Pharmaceutical Sciences, 82(3), 231-235 (1993)
Zhanguang Chen et al.
Journal of pharmaceutical and biomedical analysis, 48(3), 946-950 (2008-07-01)
A method for the specific determination of an antibacterial quaternary ammonium compound Dequalinium chloride (DQC) was described in this paper. At pH 0.5, the resonance light scattering (RLS) intensity of sodium dodecyl benzene sulfonate (SDBS) remarkably was enhanced by adding
Vladimir M Korkhov et al.
Journal of molecular biology, 377(4), 1094-1103 (2008-02-26)
EmrE is a Small Multidrug Resistance transporter (SMR) family member that mediates counter transport of protons and hydrophobic cationic drugs such as tetraphenylphosphonium (TPP+), ethidium, propidium and dequalinium. It is thought that the selectivity of the drug binding site in
[Statement of the Polish Gynecological Society expert panel concerning application of Fluomizin].
Ginekologia polska, 84(3), 237-239 (2013-05-25)
Guido Lopes dos Santos Santiago et al.
BMC research notes, 5, 151-151 (2012-03-21)
Atopobium vaginae and Gardnerella vaginalis are major markers for bacterial vaginosis. We aimed to determine the MIC and MBC range of the broad-spectrum anti-infective and antiseptic dequalinium chloride for 28 strains, belonging to 4 species of the genus Atopobium, i.e.
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