PHR1381
阿司帕坦
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
天冬酰-苯丙氨酸甲酯, N-(L-α-天冬氨酰）- L -苯丙氨酸甲酯, 天冬甜素, 阿斯巴甜
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线性分子式:
HOOCCH2CH(NH2)CONHCH(CH2C6H5)COOCH3
化学文摘社编号:
分子量:
294.30
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
245-261-3
Beilstein/REAXYS Number:
2223850
MDL number:
产品名称
阿司帕坦, Pharmaceutical Secondary Standard; Certified Reference Material
InChI key
IAOZJIPTCAWIRG-QWRGUYRKSA-N
InChI
1S/C14H18N2O5/c1-21-14(20)11(7-9-5-3-2-4-6-9)16-13(19)10(15)8-12(17)18/h2-6,10-11H,7-8,15H2,1H3,(H,16,19)(H,17,18)/t10-,11-/m0/s1
SMILES string
COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(O)=O
grade
certified reference material
pharmaceutical secondary standard
agency
traceable to Ph. Eur. A1320000
traceable to USP 1043706
API family
aspartame
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
Quality Level
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Application
这些二级标准品是合格的认证标准物质（CRM）。它们适用于多种分析应用，包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。
阿斯巴甜可用作药物标准品，用于通过高效液相色谱法测定药物制剂中的分析物。
General description
用于质量控制的制药二级标准品，为制药实验室和制造商制备内部工作标准品提供了一种方便、高性价比的替代方案。
阿斯巴甜是一种低卡路里的营养糖替代品，用于桌面甜味剂、口香糖、软饮料等。
阿斯巴甜是一种低卡路里的营养糖替代品，用于桌面甜味剂、口香糖、软饮料等。
Other Notes
在我们的NMR在线平台ChemisTwin®上可以找到本品对应的数字化标准物质。您可使用ChemisTwin®上的数字等效品鉴定您的样品并进行定量分析（使用数字化外标）。可查看该物质的NMR谱图，只需点击几次鼠标，就能进行在线样品比对。欢迎点击了解更多，开启免费试用之旅。
要查看该材料的分析证书示例，请在下面的栏位中输入LRAB9987。这只是一个示例证书，可能不是您收到的批次。
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
HPLC analysis of aspartame and saccharin in pharmaceutical and dietary formulations.
Di Pietra AM, et al.
Chromatographia, 30(3-4), 215-219 (1990)
A B Edmundson et al.
Clinical pharmacology and therapeutics, 63(5), 580-593 (1998-06-19)
The binding of sweet-tasting compounds in a human (Mcg) Bence-Jones dimer has been characterized by x-ray crystallography. Aspartame binding in this immunoglobulin fragment is remarkable. Unexpected pain relief noted by A.B.E., a crystallographer with diagnosed osteoarthritis, suggested that the accommodation
P J Janssen et al.
Toxicology, 50(1), 1-26 (1988-06-01)
In this report the neurotoxicity of aspartame and its constituent amino acids aspartic acid and phenylalanine is reviewed. The adverse reactions ascribed to the consumption of aspartame-containing products, as reported in the U.S.A., are discussed and placed in perspective with
R B Kanarek
Nutrition reviews, 52(5), 173-175 (1994-05-01)
Anecdotal evidence has led to the hypothesis that there is a relationship between sugar intake and hyperactive behavior. To assess this hypothesis, a recent study using a range of behavioral and cognitive measures evaluated the effects of diets high in
J D Fernstrom
Appetite, 11 Suppl 1, 35-41 (1988-01-01)
The ingestion of a meal of carbohydrates by fasting rats rapidly increases brain tryptophan level and serotonin (5-HT) synthesis. The rise in brain tryptophan level follows from an increase in tryptophan transport into brain, the consequence of an insulin-induced reduction
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