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S2180000

舒林酸

Name: 舒林酸
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

别名:

(Z)-5-氟-2-甲基-1-[4-(甲亚硫酰苯基)亚甲基]-1H-茚-3-醋酸

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关于此项目

经验公式（希尔记法）:

C₂₀H₁₇FO₃S

化学文摘社编号:

38194-50-2

分子量:

356.41

NACRES:

NA.24

PubChem Substance ID:

329824512

UNSPSC Code:

41116107

MDL number:

MFCD00599589

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属性

grade

pharmaceutical primary standard

API family

sulindac

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CC1=C(CC(O)=O)c2cc(F)ccc2\C1=C/c3ccc(cc3)S(C)=O

InChI

1S/C20H17FO3S/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-

InChI key

MLKXDPUZXIRXEP-MFOYZWKCSA-N

Gene Information

human ... PTGS1(5742), PTGS2(5743)

说明

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Sulindac EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

非甾体抗炎药；COX-1 的选择性抑制剂。

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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pictograms

GHS06,GHS08

signalword

Danger

hcodes

H301,H317,H334,H361

pcodes

P201 - P280 - P301 + P310 + P330 - P302 + P352

Hazard Classifications

Acute Tox. 3 Oral - Repr. 2 - Resp. Sens. 1 - Skin Sens. 1

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Clinical pharmacokinetics of sulindac. A dynamic old drug.

N M Davies et al.

Clinical pharmacokinetics, 32(6), 437-459 (1997-06-01)

Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) of the indene acetic acid class. The absorption of sulindac is rapid when given orally. Sulindac is reversibly metabolised to sulindac sulphide which has anti-inflammatory and analgesic properties and is irreversibly metabolised to

[Complete remission of a mesenteric fibromatosis after taking sulindac].

L D'Alteroche et al.

Gastroenterologie clinique et biologique, 22(12), 1098-1101 (1999-03-03)

We report the case of a 22-year-old-man having a familial adenomatous polyposis coli treated by total colectomy with ileo-rectal anastomosis. Two years after the operation, an asymptomatic mesenteric fibromatosis appeared which was nonresectable due to mesenteric vessels infiltration. Nine years

Sulindac and polyp regression.

F M Giardiello

Cancer metastasis reviews, 13(3-4), 279-283 (1994-12-01)

Sulindac is useful in regression of adenomatous polyps. In addition to orally administered sulindac, rectal preparations also appear to be efficacious [32]. However, further studies are necessary to determine whether regression of adenomas, the precursor of colorectal cancer, will cause

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货号	GTIN
S2180000	04061836917838
S2180000-2EA	04061835123117