Y0000516
格列美脲
European Pharmacopoeia (EP) Reference Standard
别名:
格列美脲
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关于此项目
经验公式（希尔记法）:
C24H34N4O5S
化学文摘社编号:
分子量:
490.62
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24
等级
pharmaceutical primary standard
API类
glimepiride
制造商/商品名称
EDQM
应用
pharmaceutical (small molecule)
包装形式
neat
储存温度
2-8°C
SMILES字符串
CCC1=C(C)CN(C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)N[C@H]3CC[C@H](C)CC3)C1=O
InChI
1S/C24H34N4O5S/c1-4-21-17(3)15-28(22(21)29)24(31)25-14-13-18-7-11-20(12-8-18)34(32,33)27-23(30)26-19-9-5-16(2)6-10-19/h7-8,11-12,16,19H,4-6,9-10,13-15H2,1-3H3,(H,25,31)(H2,26,27,30)/t16-,19-
InChI key
WIGIZIANZCJQQY-RUCARUNLSA-N
基因信息
human ... ABCC8(6833), KCNJ11(3767)
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一般描述
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
应用
格列美脲目前用于治疗 2 型糖尿病。
生化/生理作用
心脏 KATP 通道的强力阻断剂。
格列美脲是一种有效的心肌梗死 KATP 通道阻断剂，被吡那地尔激活，IC50 值为 6.8 nM。
包装
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
其他说明
Sales restrictions may apply.
警示用语：
Warning
危险声明
危险分类
Repr. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Diabetes: Add-on to metformin in T2DM--linagliptin or glimepiride?
Mikkel Christensen et al.
Nature reviews. Endocrinology, 8(10), 576-578 (2012-08-29)
K Strojek et al.
Deutsche medizinische Wochenschrift (1946), 138 Suppl 1, S16-S26 (2013-04-03)
Progressive deterioration of glycaemic control in type 2 diabetes mellitus (T2DM) often requires treatment intensification. Dapagliflozin increases urinary glucose excretion by selective inhibition of renal sodium-glucose cotransporter 2 (SGLT2). We assessed the efficacy, safety and tolerability of dapagliflozin added to
Ibtissem Oueslati et al.
La Tunisie medicale, 90(10), 735-739 (2012-10-26)
Fasting during Ramadan may be a cause of poor glycaemic control in diabetic patients. To assess glucose excursions during Ramadan by using a continuous glucose monitoring system (CGMS). The interstitial glucose level was recorded over 72 hours during Ramadan and
DPP-4 inhibition and neuroprotection: do mechanisms matter?
Richard P Shannon
Diabetes, 62(4), 1029-1031 (2013-03-23)
J L Mateos et al.
Drugs of today (Barcelona, Spain : 1998), 48 Suppl B, 1-17 (2012-10-20)
New drugs for type 2 diabetes that act on incretin metabolism have been shown to improve glycemic control, reduce body weight and have a low risk for hypoglycemia. Among these, liraglutide is the first glucagon-like peptide 1 (GLP-1) analogue approved
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