Y0000664
甲氨蝶呤杂质E
European Pharmacopoeia (EP) Reference Standard
别名:
4-{[(2,4-Diaminopteridin-6-yl)methyl]methylamino}benzoic acid
等级
pharmaceutical primary standard
API类
methotrexate
制造商/商品名称
EDQM
应用
pharmaceutical (small molecule)
包装形式
neat
储存温度
2-8°C
SMILES字符串
N(Cc2nc3c(nc(nc3N)N)nc2)(C)c1ccc(cc1)C(=O)O
InChI
1S/C15H15N7O2/c1-22(10-4-2-8(3-5-10)14(23)24)7-9-6-18-13-11(19-9)12(16)20-15(17)21-13/h2-6H,7H2,1H3,(H,23,24)(H4,16,17,18,20,21)
InChI key
LWCXZSDKANNOAR-UHFFFAOYSA-N
一般描述
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
应用
Methotrexate impurity E EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
包装
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
其他说明
Sales restrictions may apply.
警示用语：
Danger
危险分类
Acute Tox. 3 Oral - Eye Irrit. 2 - Muta. 2 - Repr. 1B - Skin Irrit. 2
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Eva Klapkova et al.
Clinical laboratory, 57(7-8), 599-606 (2011-09-06)
A modified high performance liquid chromatographic (HPLC) method has been developed for the simultaneous determination of methotrexate (MTX) and its main metabolite 7-hydroxymethotrexate (7-OHMTX) and compared to the immunochemical fluorescence polarization immunoassay (FPIA2) determination of methotrexate. Methotrexate was determined by
R G Smith et al.
Biomedical mass spectrometry, 8(4), 144-148 (1981-04-01)
Folic acid and several analogs have been characterized as their permethylated derivatives. These derivatives are readily evaporated from the solid probe and provide spectra with abundant molecular ions and characteristic fragment ions. This method has been used to confirm the
L M DeAngelis et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 14(7), 2145-2149 (1996-07-01)
This study was a pilot project to assess the safety and efficacy of carboxypeptidase G2 (CPG2) rescue from high-dose (HD) methotrexate (MTX) in patients with recurrent cerebral lymphoma. Four patients with recurrent primary CNS lymphoma (PCNSL) were studied. Patients received
Commentary.
Michael C Milone
Clinical chemistry, 56(12), 1795-1796 (2010-12-02)
D A Cairnes et al.
Journal of chromatography, 231(1), 103-110 (1982-08-13)
An automated high-performance liquid chromatographic system is described for separation and quantitation of the antineoplastic drug methotrexate and metabolites, and the antibiotic sulfamethoxazole in body fluids. The 40-min analysis utilizes a reversed-phase C18 column and gradient elution with detection by
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