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文件

Y0000849

克霉唑

Name: 克霉唑
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

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别名:

1-[（2-氯苯基）二苯基甲基]-1-H咪唑, 1-（o-氯-α，α-二苯基苄基）咪唑, 1-（o-氯三苯）咪唑

经验公式（希尔记法）:

C₂₂H₁₇ClN₂

CAS号:

23593-75-1

分子量:

344.84

MDL编号:

MFCD00057220

PubChem化学物质编号:

329831188

NACRES:

NA.24

等级

pharmaceutical primary standard

API类

clotrimazole

制造商/商品名称

EDQM

应用

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

SMILES字符串

Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4

InChI

1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H

InChI key

VNFPBHJOKIVQEB-UHFFFAOYSA-N

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一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Clotrimazole for peak identification EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

PHR1058

克霉唑, Pharmaceutical Secondary Standard; Certified Reference Material

1141024

警示用语：

Warning

危险声明

H302 - H315 - H319 - H410

预防措施声明

P264 - P270 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338

危险分类

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

分析证书(COA)

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示例

T1503

货号

25G

包装规格/数量

其它示例：

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

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Antifungal Azoles: Structural Insights into Undesired Tight Binding to Cholesterol-Metabolizing CYP46A1.

Natalia Mast et al.

Molecular pharmacology, 84(1), 86-94 (2013-04-23)

Although there are currently three generations of antifungal azoles on the market, even the third-generation agents show undesirable interactions with human cytochrome P450 (P450) enzymes. CYP46A1 is a cholesterol-metabolizing P450 in the brain that tightly binds a number of structurally

Colloidal aggregation causes inhibition of G protein-coupled receptors.

Maria F Sassano et al.

Journal of medicinal chemistry, 56(6), 2406-2414 (2013-02-27)

Colloidal aggregation is the dominant mechanism for artifactual inhibition of soluble proteins, and controls against it are now widely deployed. Conversely, investigating this mechanism for membrane-bound receptors has proven difficult. Here we investigate the activity of four well-characterized aggregators against

Bioavailability of the imidazole antifungal agent clotrimazole and its effects on key biotransformation genes in the common carp (Cyprinus carpio).

Jenna Corcoran et al.

Aquatic toxicology (Amsterdam, Netherlands), 152, 57-65 (2014-04-15)

Clotrimazole (CTZ) is a persistent imidazole antifungal agent which is frequently detected in the aquatic environment and predicted to bio-concentrate in fish. Common carp (Cyprinus carpio) were exposed to mean measured concentrations of either 1.02 or 14.63μgl(-1) CTZ for 4

Akt inhibition promotes hexokinase 2 redistribution and glucose uptake in cancer cells.

Catherine L Neary et al.

Journal of cellular physiology, 228(9), 1943-1948 (2013-05-01)

Hexokinase II (HK2), the enzyme that catalyzes the first committed step of glycolysis, is overexpressed in many cancers, as is the central signaling kinase Akt. Akt activity promotes HK2 association with the mitochondria, as well as glucose uptake by cancer

Endothelial nitric oxide synthase-independent release of nitric oxide in the aorta of the spontaneously hypertensive rat.

Yingzi Zhao et al.

The Journal of pharmacology and experimental therapeutics, 344(1), 15-22 (2012-09-26)

In the aorta of male spontaneously hypertensive rats (SHR), but not in that of normotensive Wistar-Kyoto rats (WKY), contractions to phenylephrine obtained in the presence of L-NAME [inhibitor of nitric oxide synthase (NOS)] and indomethacin (inhibitor of cyclooxygenase) are inhibited

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