产品名称
蛇床子素, European Pharmacopoeia (EP) Reference Standard
InChI
1S/C15H16O3/c1-10(2)4-7-12-13(17-3)8-5-11-6-9-14(16)18-15(11)12/h4-6,8-9H,7H2,1-3H3
SMILES string
COc1ccc2C=CC(=O)Oc2c1C\C=C(\C)C
InChI key
MBRLOUHOWLUMFF-UHFFFAOYSA-N
grade
pharmaceutical primary standard
API family
osthole
manufacturer/tradename
EDQM
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
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Biochem/physiol Actions
传统中药 蛇床子的有效成分，具有抗炎、镇痛、降脂等作用。在鹌鹑模型中显著降低脂质蓄积。它对MPP（+）诱导的PC12细胞中细胞毒性的神经保护作用支持使用蛇床子素作为治疗神经退行性疾病的治疗剂。在 HER2 过度表达的乳腺癌细胞中抑制脂肪酸合成酶的表达表明蛇床子素有望成为化疗药物。
Application
Osthole EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.
Other Notes
Sales restrictions may apply.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Osthole attenuates lipid accumulation, regulates the expression of inflammatory mediators, and increases antioxidants in FL83B cells.
Huang W C, et al.
Biomedicine and Pharmacotherapy, 91, 78-87 (2017)
Ola D Alabi et al.
Life sciences, 102(2), 105-110 (2014-03-25)
Osthole, a coumarin derivative, has been used in Chinese medicine and studies have suggested a potential use in treatment of diabetes and cancers. Therefore, we investigated the effects of osthole and other coumarins on GLUT1 activity in two cell lines
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