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关于此项目
经验公式（希尔记法）:
C13H12N2O5S
化学文摘社编号:
分子量:
308.31
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
InChI
1S/C13H12N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h2-9,14H,1H3
SMILES string
CS(NC1=C(OC2=CC=CC=C2)C=C([N+]([O-])=O)C=C1)(=O)=O
InChI key
HYWYRSMBCFDLJT-UHFFFAOYSA-N
grade
pharmaceutical primary standard
API family
nimesulide
manufacturer/tradename
EDQM
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
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Application
Nimesulide for peak identification EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Biochem/physiol Actions
高选择性环氧化酶-2 抑制剂。
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.
Other Notes
Sales restrictions may apply.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
H Suleyman et al.
Current medicinal chemistry, 15(3), 278-283 (2008-03-13)
In this review it is shown that nimesulide, a selective cyclooxigenase-2 (COX-2) inhibitor, is different from other selective COX-2 inhibitors and classical non-steroidal anti-inflammatory drugs (NSAIDs). The anti-inflammatory effect mechanism of nimesulide (inhibition of inflammatory mediators) is similar to other
Muhammad Hanif et al.
Pakistan journal of pharmaceutical sciences, 27(4), 785-792 (2014-07-13)
Simple and cost effective study consisting of three steps, comparison of micromeritic properties of different blends i.e. placebo without API and Nimesulide containing, Use of central composite design (CCRD) for intermediate release Nimesulide tablets and stability results of three selected
M Page et al.
Annales francaises d'anesthesie et de reanimation, 27(9), 742-746 (2008-09-02)
Nimesulide is a non-steroidal anti-inflammatory drug available in several European countries. A hepatic toxicity due to nimesulide has been reported but fatal cases remain rare. We report the case of a 49-year-old woman treated by nimesulide during three days, admitted
E C Huskisson
Clinical and experimental rheumatology, 19(1 Suppl 22), S21-S25 (2001-04-12)
World-wide experience with nimesulide confirms that it is an effective anti-inflammatory drug in the treatment of osteoarthritis. A review of several studies in this condition confirms that nimesulide is at least as efficacious as other commonly used compounds. The safety
Lorena Pochini et al.
Biochemical pharmacology, 89(3), 422-430 (2014-04-08)
The effect of pharmaceutical compounds on the rat kidney B0AT1 transporter in proteoliposomes has been screened. To this aim, inhibition of the transport activity by the different compounds was measured on Na(+)-[(3)H]glutamine co-transport in the presence of membrane potential positive
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