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文件

Y0001253

左乙拉西坦

Name: 左乙拉西坦
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

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别名:

(αS)-α-乙基-2-氧代-1-吡咯烷乙酰胺, 2（S）-（2-氧吡咯烷-1-基）丁酰胺, Keppra^®

经验公式（希尔记法）:

C₈H₁₄N₂O₂

CAS号:

102767-28-2

分子量:

170.21

MDL编号:

MFCD03265610

PubChem化学物质编号:

329831325

NACRES:

NA.24

等级

pharmaceutical primary standard

API family

levetiracetam

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

SMILES string

CC[C@H](N1CCCC1=O)C(N)=O

InChI

1S/C8H14N2O2/c1-2-6(8(9)12)10-5-3-4-7(10)11/h6H,2-5H2,1H3,(H2,9,12)/t6-/m0/s1

InChI key

HPHUVLMMVZITSG-LURJTMIESA-N

Gene Information

human ... CACNA1B(774) , SV2A(9900)

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一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Levetiracetam EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

生化/生理作用

左乙拉西坦是一种具有抗癫痫活性的吡咯烷。左乙拉西坦的立体选择性结合仅限于中枢神经系统的突触质膜，而在周围组织中不发生立体选择性结合。左乙拉西坦在不影响正常神经元兴奋性的情况下抑制簇状放电，这表明它可以选择性地阻止癫痫样簇状放电的超同步和发作活动的传播。

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

警示用语：

Warning

危险声明

H302 - H319

预防措施声明

P301 + P312 + P330 - P305 + P351 + P338

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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示例

T1503

货号

25G

包装规格/数量

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705578-5MG-PW

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The local peripheral antihyperalgesic effect of levetiracetam and its mechanism of action in an inflammatory pain model.

Radica M Stepanović-Petrović et al.

Anesthesia and analgesia, 115(6), 1457-1466 (2012-11-13)

We have recently shown that levetiracetam, administered systemically, exerts an antihyperalgesic effect in a rat inflammatory pain model. In this study, we examined whether levetiracetam has local peripheral antihyperalgesic/anti-edematous effects in the same model of localized inflammation and whether opioidergic

Inhibitory effects of levetiracetam on the high-voltage-activated L-type Ca²⁺ channels in hippocampal CA3 neurons of spontaneously epileptic rat (SER).

Hai-Dun Yan et al.

Brain research bulletin, 90, 142-148 (2012-10-31)

Levetiracetam (LEV) is a widely used antiepileptic agent for partial refractory epilepsy in humans. LEV has unique antiepileptic effects in that it does not inhibit electroshock- or pentylenetetrazol-induced convulsion, but does inhibit seizures in kindling animal and spontaneously epileptic rat

Levetiracetam versus carbamazepine in patients with late poststroke seizures: a multicenter prospective randomized open-label study (EpIC Project).

D Consoli et al.

Cerebrovascular diseases (Basel, Switzerland), 34(4), 282-289 (2012-11-07)

Strokes are the leading cause of epileptic seizures in adults and account for 50% of seizures in those over the age of 65 years. The use of antiepileptic drugs to prevent recurrent poststroke seizures is recommended. One hundred and twenty-eight

Levetiracetam improves verbal memory in high-grade glioma patients.

Marjolein de Groot et al.

Neuro-oncology, 15(2), 216-223 (2012-12-13)

Treatment of high-grade glioma (HGG) patients with anti-epileptic drugs (AEDs) has met with various side effects, such as cognitive deterioration. The cognitive effects of both older and newer AEDs in HGG patients are largely unknown. The aim of this study

Levetiracetam as alternative stage two antiepileptic drug in status epilepticus: a systematic review.

Johan Zelano et al.

Seizure, 21(4), 233-236 (2012-02-11)

The role of new antiepileptic drugs (AED) in the treatment of status epilepticus (SE) is of interest, especially in benzodiazepine-resistant status epilepticus where phenytoin is deemed inappropriate due to allergy or comorbidity. Levetiracetam (LEV) is a new AED with few

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