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Y0001389

坎地沙坦酯

European Pharmacopoeia (EP) Reference Standard

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别名:
坎地沙坦酯, 2-乙氧基-1-[[2′-(2H-四唑-5-基)[1,1′-联苯] -4-基]甲基] -1H-苯并咪唑-7-羧酸1-[[（（环己氧基）羰基]氧基]乙酯, TCV 116, TCY 116
经验公式（希尔记法）:
C33H34N6O6
CAS号:
145040-37-5
分子量:
610.66
MDL编号:
MFCD00871371
PubChem化学物质编号:
329831397
NACRES:
NA.24

等级

pharmaceutical primary standard

API类

candesartan

制造商/商品名称

EDQM

应用

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

SMILES字符串

CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc4ccc(cc4)-c5ccccc5-c6nnn[nH]6

InChI

1S/C33H34N6O6/c1-3-42-32-34-28-15-9-14-27(31(40)43-21(2)44-33(41)45-24-10-5-4-6-11-24)29(28)39(32)20-22-16-18-23(19-17-22)25-12-7-8-13-26(25)30-35-37-38-36-30/h7-9,12-19,21,24H,3-6,10-11,20H2,1-2H3,(H,35,36,37,38)

InChI key

GHOSNRCGJFBJIB-UHFFFAOYSA-N

基因信息

human ... AGTR1(185)

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相关类别

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Candesartan cilexetil for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

生化/生理作用

坎地沙坦酯是有效的血管紧张素 II 受体拮抗剂坎地沙坦的前药形式。 该前药在肠道内被酯酶裂解释，并放活性分子。

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

相关产品

产品编号
说明
价格

Y0001388

坎地沙坦酯, European Pharmacopoeia (EP) Reference Standard

Y0001387

坎地沙坦酯, European Pharmacopoeia (EP) Reference Standard

1087803

坎地沙坦酯, United States Pharmacopeia (USP) Reference Standard

1087814

Candesartan cilexetil Related Compound A, United States Pharmacopeia (USP) Reference Standard

1087825

Candesartan cilexetil Related Compound B, United States Pharmacopeia (USP) Reference Standard

1087847

Candesartan cilexetil Related Compound D, United States Pharmacopeia (USP) Reference Standard

1087869

Candesartan cilexetil Related Compound F, United States Pharmacopeia (USP) Reference Standard

1087870

Candesartan cilexetil Related Compound G, United States Pharmacopeia (USP) Reference Standard

PHR1854

坎地沙坦酯, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2035

坎地沙坦酯杂质 C, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2021

坎地沙坦酯相关化合物G, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2036

坎地沙坦酯杂质 E, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2020

坎地沙坦酯相关化合物 F, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2018

坎地沙坦酯相关化合物B, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2022

坎地沙坦酯杂质I, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2019

坎地沙坦酯相关化合物 D, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2017

坎地沙坦酯相关化合物A, Pharmaceutical Secondary Standard; Certified Reference Material

BP1248

坎地沙坦酯, British Pharmacopoeia (BP) Reference Standard

BP1249

Candesartan Cilexetil Impurity Standard, British Pharmacopoeia (BP) Reference Standard

象形图

Health hazardEnvironment
GHS08,GHS09

警示用语：

Warning

危险声明

H361 - H400

预防措施声明

P280

危险分类

Aquatic Acute 1 - Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Sheridan M Hoy et al.
American journal of cardiovascular drugs : drugs, devices, and other interventions, 10(5), 335-342 (2010-09-24)
Candesartan cilexetil is the orally administered prodrug of candesartan, an angiotensin II subtype 1 receptor antagonist. The pharmacokinetics (area under the plasma concentration-time curve and maximum plasma concentration) of candesartan do not appear to be affected by age, sex, or
Caroline Fenton et al.
Drugs, 65(4), 537-558 (2005-03-01)
Candesartan cilexetil is the orally administered pro-drug of candesartan, a highly selective antagonist of the angiotensin II subtype 1 receptor that mediates the pressor activities of angiotensin II. Candesartan cilexetil is widely used for the treatment of hypertension and has
T Naka et al.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 120(12), 1261-1275 (2001-02-24)
Blockade of the action of angiotensin II (AII) has long been a target for the development of novel antihypertensive agents. We recently discovered a novel class of potent nonpeptide AII receptor antagonists, benzimidazole-7-carboxylic acids including candesartan. Candesartan is a highly
Gerd Bönner et al.
Current medical research and opinion, 21(6), 935-940 (2005-06-23)
Candesartan cilexetil is a highly potent and long-acting angiotensin II type I (AT1) receptor antagonist. This short review summarises results of clinical studies focusing on the duration of action of candesartan cilexetil. Results of previous clinical studies indicate that candesartan
Peter A Meredith
Current medical research and opinion, 23(7), 1693-1705 (2007-06-26)
Therapeutic interventions that block the renin-angiotensin-aldosterone system (RAAS) have an important role in slowing the progression of cardiovascular risk actors to established cardiovascular diseases. In recent years, angiotensin receptor blockers (ARBs) have emerged as effective and well-tolerated alternatives to an
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