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Merck
CN

Y0001432

米诺地尔,系统适用性测试标准品

European Pharmacopoeia (EP) Reference Standard

别名:

米诺地尔, 6-(1-哌啶基)-2,4-嘧啶二胺 3-氧化物, 6-(1-哌啶基)嘧啶-2,4-二胺 3-氧化物

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关于此项目

经验公式(希尔记法):
C9H15N5O
化学文摘社编号:
分子量:
209.25
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
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产品名称

米诺地尔,系统适用性测试标准品, European Pharmacopoeia (EP) Reference Standard

InChI

1S/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6,11,15H,1-5,10H2

SMILES string

NC1=CC(=NC(=N)N1O)N2CCCCC2

InChI key

ZIMGGGWCDYVHOY-UHFFFAOYSA-N

grade

pharmaceutical primary standard

API family

minoxidil

manufacturer/tradename

EDQM

mp

272-274 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

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Application

用于系统适用性的米诺地尔EP参考标准品的预期用途是欧洲药典规定的实验室测试。

Biochem/physiol Actions

激活 ATP 激活的 K+ 通道;血管扩张剂;减缓或停止脱发,促进头发再生。

General description

本品按现行药典规定交付。该产品的所有支持信息,包括SDS和任何产品信息宣传页均由药典发行机构制定并发布。如需更多信息和支持,请见现行药典的网站。

Other Notes

可能适用相应的销售限制条件。

Packaging

本品按照现行药典要求提供。有关当前单位数量,请见EDQM 参考目录

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


历史批次信息供参考:

分析证书(COA)

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S E Whitmore
Archives of dermatology, 128(5), 653-656 (1992-05-01)
The correct selection of vehicles for patch testing specific substances is essential in the evaluation of suspected allergic contact dermatitis. A reaction to a chemical may be dependent not only on the concentration tested but also on the vehicle in
D A Sica et al.
Journal of clinical hypertension (Greenwich, Conn.), 3(2), 110-114 (2001-06-21)
Minoxidil is a direct vasodilator that has been in use for over two decades. It is used primarily to reduce blood pressure in hypertensives who have been poorly controlled on various multidrug regimens. Although minoxidil is extremely effective, its usefulness
Minoxidil use in female alopecia.
W M Wong et al.
The Annals of pharmacotherapy, 28(7-8), 890-891 (1994-07-01)
Domenic A Sica
Journal of clinical hypertension (Greenwich, Conn.), 6(5), 283-287 (2004-05-11)
Minoxidil is a direct vasodilator introduced in the early 1970s for the treatment of hypertension. It is capable of reducing blood pressure in most persons with resistant hypertension where therapy has failed with multidrug regimens. Minoxidil's effect can be limited
Alfredo Rossi et al.
Recent patents on inflammation & allergy drug discovery, 6(2), 130-136 (2012-03-14)
Minoxidil, a vasodilator medication known for its ability to slow or stop hair loss and promote hair regrowth, was first introduced, exclusively as an oral drug, to treat high blood pressure. It was however discovered to have the important side-effect

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