Merck
CN
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文件

Y0001522

阿那曲唑

European Pharmacopoeia (EP) Reference Standard

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别名:
2;2"-[5-(1H-1;2;4-三唑-1-基甲基)-1, 3-苯] 双(2-甲基丙腈, ICI-D1033, ZD1033, a,a,a′,a′-四甲基-5-(1-H-1,2,4-三唑-1-甲基)-1,3-二乙氰苯, 安美达锭
经验公式（希尔记法）:
C17H19N5
CAS号:
120511-73-1
分子量:
293.37
NACRES:
NA.24

等级

pharmaceutical primary standard

API类

anastrozole

制造商/商品名称

EDQM

应用

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

InChI

1S/C17H19N5/c1-16(2,9-18)14-5-13(8-22-12-20-11-21-22)6-15(7-14)17(3,4)10-19/h5-7,11-12H,8H2,1-4H3

InChI key

YBBLVLTVTVSKRW-UHFFFAOYSA-N

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相关类别

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Anastrozole EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

象形图

Exclamation markHealth hazard
GHS07,GHS08

警示用语：

Danger

危险声明

H302 - H360FD

危险分类

Acute Tox. 4 Oral - Repr. 1B

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Raimund Jakesz
Expert opinion on drug metabolism & toxicology, 2(2), 301-312 (2006-07-27)
Anastrozole is a nonsteroidal, third-generation aromatase inhibitor, which is heralded as an effective alternative endocrine therapy to tamoxifen in postmenopausal women with hormone-responsive breast cancer. Anastrozole has a high affinity for aromatase, a CYP enzyme involved in estrogen synthesis, and
Tuna Yucel et al.
Biomaterials, 35(30), 8613-8620 (2014-07-11)
A silk-protein based reservoir rod was developed for zero-order and long-term sustained drug delivery applications. Silk reservoir rod formulations were processed in three steps. First, a regenerated silk fibroin solution, rich in random-coil content was transformed into a tubular silk
Catherine M Kelly et al.
Expert opinion on drug safety, 9(6), 995-1003 (2010-10-07)
Anastrozole is a third-generation aromatase inhibitor used in the adjuvant setting for the treatment of hormone receptor-positive breast cancer. Several adjuvant randomized trials have reported greater efficacy for anastrozole when compared to tamoxifen. This review discusses the mechanism of action
Peter H Graham
Expert opinion on pharmacotherapy, 8(14), 2347-2357 (2007-10-12)
Anastrozole is a third-generation aromatase inhibitor with an extensive evidence base to preferentially support its use in multiple scenarios in endocrine-responsive breast cancer. These include neoadjuvant treatment, immediate and delayed adjuvant treatment, salvage treatment and first-line treatment of advanced breast
Ravi Kacker et al.
The Journal of urology, 191(4), 1072-1076 (2013-10-29)
Testosterone deficiency is a known risk factor for osteopenia and osteoporosis in older men. Less is known about the impact of testosterone deficiency on bone mineral density in younger men. We retrospectively reviewed the charts at an andrology/infertility clinic and
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