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A7929

L-(+)-2-氨基-4-膦酰基丁酸

Name: <SC>L</SC>-(+)-2-氨基-4-膦酰基丁酸
Brand: SIGMA

optical purity optical purity: ≥95% (HPLC, Marfey′s reagent)

别名:

L-AP-4, L-AP4

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关于此项目

经验公式（希尔记法）:

C₄H₁₀NO₅P

化学文摘社编号:

23052-81-5

分子量:

183.10

NACRES:

NA.32

PubChem Substance ID:

24891296

UNSPSC Code:

12352106

MDL number:

MFCD00083244

Form:

powder

Quality level:

200

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属性

form

powder

Quality Level

200

optical purity

optical purity: ≥95% (HPLC, Marfey′s reagent)

SMILES string

N[C@@H](CCP(O)(O)=O)C(O)=O

InChI

1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1

InChI key

DDOQBQRIEWHWBT-VKHMYHEASA-N

Gene Information

human ... GRM1(2911), GRM2(2912), GRM3(2913), GRM4(2914), GRM6(2916), GRM7(2917), GRM8(2918)
rat ... Grm1(24414), Grm2(24415), Grm4(24417), Grm5(24418), Grm6(24419), Grm7(81672)

说明

Biochem/physiol Actions

mGluR₄ 和 mGluR₆ 代谢型谷氨酸受体激动剂。

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存储类别

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000215229

0000215221

0000184519

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A virtual screening hit reveals new possibilities for developing group III metabotropic glutamate receptor agonists.

Chelliah Selvam et al.

Journal of medicinal chemistry, 53(7), 2797-2813 (2010-03-12)

(R)-PCEP (3-amino-3-carboxypropyl-2'-carboxyethyl phosphinic acid, 1), a new metabotropic glutamate receptor 4 (mGlu4R) agonist, was discovered in a previously reported virtual screening. The (S)-enantiomer and a series of derivatives were synthesized and tested on recombinant mGlu4 receptors. A large number of

Activity-dependent synaptic integration and modulation of bilateral excitatory inputs in an auditory coincidence detection circuit.

Yong Lu et al.

The Journal of physiology, 596(10), 1981-1997 (2018-03-25)

Binaural excitatory inputs to coincidence detection neurons in nucleus laminaris (NL) play essential roles in interaural time difference coding for sound localization. Here, we show that the two excitatory inputs are physiologically nearly completely segregated. Synaptic integration shows linear summation

LRIT3 is Required for Nyctalopin Expression and Normal ON and OFF Pathway Signaling in the Retina.

Nazarul Hasan et al.

eNeuro, 7(1) (2020-01-22)

The first retinal synapse, photoreceptor→bipolar cell (BC), is both anatomically and functionally complex. Within the same synaptic region, a change in presynaptic glutamate release is sensed by both ON BCs (DBCs) via the metabotropic glutamate receptor 6 (mGluR6), and OFF

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全球贸易项目编号

货号	GTIN
A7929-1MG	04061826740934
A7929-.5MG	04061833002018