C1868
抗-钙通道CaV3.2（α1H） 兔抗
affinity isolated antibody, lyophilized powder
别名:
Anti-CACNA1HB, Anti-Cav3.2, Anti-ECA6, Anti-EIG6, Anti-HALD4
产品名称
抗-钙通道CaV3.2（α1H） 兔抗, affinity isolated antibody, lyophilized powder
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
rat
technique(s)
western blot: 1:200 using lysate from the ND7/23 cell line
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
rat ... Cacna1h(114862)
Application
兔生产的抗钙通道CaV3.2 （α1H）抗体适用于使用ND7/23细胞系裂解物以1：200的稀释度进行蛋白质印迹分析。
成功使用该抗体的应用以及相关的同行评审论文如下所示。
蛋白质印迹（1篇论文）
蛋白质印迹（1篇论文）
Biochem/physiol Actions
钙通道，电压依赖性，T型，α1H亚基（CACNA1H）在调节大脑中的神经元兴奋性和网络振荡中起着至关重要的作用。该基因的突变与各种形式的特发性全身性癫痫有关。CACNA1H中的功能获得突变通过直接改变神经元电学特性和通过改变基因表达间接增加癫痫发作敏感性。CACNA1H是静息膜电位附近Ca2+进入的重要介体。它在疼痛信号的处理中起着关键作用，并且可以作为开发用于对目前可用的镇痛药具有抗性的顽固性疼痛的治疗的药物的新靶标。CACNA1H上调参与炎症性，神经性和内脏疼痛的病理生理。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
钙通道，电压依赖性，T型，α1H亚基（CACNA1H）是人类中由CACNA1H基因编码的蛋白，并定位于16p13.3号染色体。蛋白质是膜蛋白机制，可选择性渗透外部钙离子。α1H通道对米贝拉地尔（一种非二氢吡啶Ca2+ 通道阻滞剂）敏感。CACNA1H在初级传入神经元的外周和中枢末端大量表达，调节神经元兴奋性和兴奋性神经递质的释放。
Immunogen
对应于大鼠CaV3.2氨基酸残基581-595的合成肽CHVEGPQERARVAHS。表位位置：连接D1-D2的细胞内环。小鼠，牛和犬具有14/15个相同的残基；人具有13/15个相同的残基。
Physical form
从含有1%牛血清白蛋白和0.05%叠氮化钠的磷酸盐缓冲盐水（pH 7.4）中冻干。
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存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
含少量动物源组分生物产品
常规特殊物品
常规特殊物品
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T-type CaV3 channels are important mediators of Ca(2+) entry near the resting membrane potential. Little is known about the molecular mechanisms responsible for channel activation. Homology models based upon the high-resolution structure of bacterial NaV channels predict interaction between the
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The Journal of physiology, 592(4), 795-809 (2013-11-28)
T-type calcium channels play essential roles in regulating neuronal excitability and network oscillations in the brain. Mutations in the gene encoding Cav3.2 T-type Ca(2+) channels, CACNA1H, have been found in association with various forms of idiopathic generalized epilepsy. We and
K E Rose et al.
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