M4796
(±)-α-Methyl-(4-carboxyphenyl)glycine
别名:
(±)-MCPG
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关于此项目
经验公式（希尔记法）:
C10H11NO4
化学文摘社编号:
分子量:
209.20
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h2-5H,11H2,1H3,(H,12,13)(H,14,15)
SMILES string
CC(N)(C(O)=O)c1ccc(cc1)C(O)=O
InChI key
DNCAZYRLRMTVSF-UHFFFAOYSA-N
Gene Information
human ... GRM1(2911), GRM2(2912), GRM3(2913), GRM5(2915)
rat ... Grm1(24414)
Biochem/physiol Actions
Competitive antagonist at Group 1 (mGluR1 and mGluR5) and Group 2 (mGluR2 and mGluR3) metabotropic glutamate receptors.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
L S Thomas et al.
Neuropharmacology, 39(9), 1554-1566 (2000-06-16)
In the present study we have examined the role of presynaptic group I metabotropic glutamate (mGlu) receptors in the control of neuronal glutamate release using rat forebrain slices pre-loaded with [(3)H]D-aspartate. We have also addressed the question of which group
Ana C Takakura et al.
Experimental physiology, 96(10), 989-999 (2011-07-12)
In the present study, we evaluated the role of glutamatergic mechanisms in the retrotrapezoid nucleus (RTN) in changes of splanchnic sympathetic nerve discharge (sSND) and phrenic nerve discharge (PND) elicited by central and peripheral chemoreceptor activation. Mean arterial pressure (MAP)
Hilary Gerstein et al.
Neurobiology of learning and memory, 97(1), 17-29 (2011-09-29)
Homer1 belongs to a family of scaffolding proteins that interact with various post-synaptic density proteins including group I metabotropic glutamate receptors (mGluR1/5). Previous research in our laboratory implicates the Homer1c isoform in spatial learning. Homer1 knockout mice (H1-KO) display cognitive
D D Schoepp et al.
Neuropharmacology, 36(1), 1-11 (1997-01-01)
The novel compound LY354740 is a conformationally constrained analog of glutamate, which was designed for interaction at metabotropic glutamate (mGlu) receptors. In this paper the selectivity of LY354740 for recombinant human mGlu receptor subtypes expressed in non-neuronal (RGT) cells is
Marta Navarrete et al.
Neuron, 68(1), 113-126 (2010-10-06)
Endocannabinoids and their receptor CB1 play key roles in brain function. Astrocytes express CB1Rs that are activated by endocannabinoids released by neurons. However, the consequences of the endocannabinoid-mediated neuron-astrocyte signaling on synaptic transmission are unknown. We show that endocannabinoids released
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