产品名称
乙酰丙嗪 马来酸盐, United States Pharmacopeia (USP) Reference Standard
InChI
1S/C19H22N2OS.C4H4O4/c1-14(22)15-9-10-19-17(13-15)21(12-6-11-20(2)3)16-7-4-5-8-18(16)23-19;5-3(6)1-2-4(7)8/h4-5,7-10,13H,6,11-12H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
SMILES string
OC(=O)\C=C/C(O)=O.CN(C)CCCN1c2ccccc2Sc3ccc(cc13)C(C)=O
InChI key
FQRHOOHLUYHMGG-BTJKTKAUSA-N
grade
pharmaceutical primary standard
API family
acepromazine
manufacturer/tradename
USP
application(s)
pharmaceutical (small molecule)
format
neat
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Biochem/physiol Actions
乙酰丙嗪是一种吩噻嗪类抗精神病药，仅用作兽药（马、狗和猫）。该化合物是抗精神病药物氯丙嗪（＃C8138）的类似物。该药物被认为可以阻断大脑中的多巴胺受体。最近发现该化合物抑制 ABCG2 转运蛋白，该蛋白在肿瘤中的过表达与耐药性有关。
非典型抗精神病药。
Analysis Note
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
Application
Acepromazine maleate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
- Acepromazine Maleate Injection
- Acepromazine Maleate Tablets
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Other Notes
Sales restrictions may apply.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral - STOT SE 3
target_organs
Central nervous system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Journal of the American Association for Laboratory Animal Science : JAALAS, 53(5), 494-501 (2014-09-26)
The goal of the current study was to compare the efficacy, adverse effects, and plasma buprenorphine concentrations of sustained-release buprenorphine (SRB) and buprenorphine after subcutaneous administration in dogs undergoing ovariohysterectomy. In a prospective, randomized, blinded design, 20 healthy adult female
Samer M Jaber et al.
Journal of the American Association for Laboratory Animal Science : JAALAS, 53(6), 684-691 (2015-02-05)
Extending a surgical plane of anesthesia in mice by using injectable anesthetics typically is accomplished by repeat-bolus dosing. We compared the safety and efficacy of redosing protocols administered either during an anesthetic surgical plane (maintaining a continuous surgical plane, CSP)
Cathryn M Kolka et al.
Metabolism: clinical and experimental, 64(2), 330-337 (2014-12-04)
Insulin injected directly into skeletal muscle diffuses rapidly through the interstitial space to cause glucose uptake, but this is blocked in insulin resistance. As glucotoxicity is associated with endothelial dysfunction, the observed hyperglycemia in diet-induced obese dogs may inhibit insulin
Amadeu Gavaldà et al.
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This study characterised the in vitro and in vivo profiles of two novel long-acting muscarinic antagonists, aclidinium bromide and glycopyrronium bromide, using tiotropium bromide and ipratropium bromide as comparators. All four antagonists had high affinity for the five muscarinic receptor sub-types (M1-M5);
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Journal of the science of food and agriculture, 95(3), 598-606 (2014-06-21)
The use of xenobiotic compounds in animal husbandry has given rise to consumer anxieties regarding residual risk and food safety. Thus, animal tissues have become main samples for residue analysis and food safety for sedatives. In this study, a rapid
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